Results 71 to 80 of about 565,406 (340)

Effects of Thermal Treatment on the Physical Properties of Edible Calcium Alginate Gel Beads: Response Surface Methodological Approach

open access: yesFoods, 2019
Calcium alginate gel (CAG) has been widely investigated for the development of artificial foods; however, there are few studies on its thermal stability.
Seonghui Kim   +3 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

An improved encapsulation protocol for regrowth and conservation of four ornamental species

open access: yesActa Societatis Botanicorum Poloniae, 2017
The encapsulation technology, initially developed for clonal propagation through the production of synthetic seeds with somatic embryos, is currently proposed for use with non-embryogenic explants, such as buds and nodal segments (unipolar propagules ...
Carla Benelli   +2 more
doaj   +1 more source

Dynamical Eigenmodes of Star and Tadpole Polymers

open access: yes, 2013
The dynamics of phantom bead-spring chains with the topology of a symmetric star with $f$ arms and tadpoles ($f=3$, a special case) is studied, in the overdamped limit.
Barkema, Gerard T.   +2 more
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Lab‐in‐a‐Bead: Magnetic Janus Bead Probe for the Detection of Biomarkers in Blood

open access: yesAdvanced Materials Interfaces, 2023
Remotely handled miniaturized colorimetric sensor platforms with multiple functionalities are able to mimic conventional laboratory operations with reduced assets.
Udara Bimendra Gunatilake   +5 more
doaj   +1 more source

Jacobi Elliptic Functions and the Complete Solution to the Bead on the Hoop Problem

open access: yes, 2012
Jacobi elliptic functions are flexible functions that appear in a variety of problems in physics and engineering. We introduce and describe important features of these functions and present a physical example from classical mechanics where they appear: a
Baker, Thomas E., Bill, Andreas
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

One-step affinity purification of fusion proteins with optimal monodispersity and biological activity: application to aggregation-prone HPV E6 proteins

open access: yesMicrobial Cell Factories, 2018
Background Bacterial expression and purification of recombinant proteins under homogeneous active form is often challenging. Fusion to highly soluble carrier proteins such as Maltose Binding Protein (MBP) often improves their folding and solubility, but ...
Anna Bonhoure   +7 more
doaj   +1 more source

Method to Determine the Optimal Aptamer-to-Bead Ratio by Using Flow Cytometry

open access: yesScientifica, 2023
Research on the effective attachment of aptamers to beads, which is essential for using aptamers, has made relatively little progress. Here, we demonstrate a new method based on flow cytometry to determine the optimal aptamer-to-bead ratio for aptamer ...
Sun Young Lee   +5 more
doaj   +1 more source

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