Results 71 to 80 of about 700,478 (387)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Microrheological Studies of Regenerated Silk Fibroin Solution by Video Microscopy

open access: yes, 2007
We have carried out studies on the rheological properties of regenerated silk fibroin (RSF) solution using video microscopy. The degummed silk from the Bombyx mori silkworm was used to prepare RSF solution by dissolving it in calcium nitrate tetrahydrate-
A, Raghu   +2 more
core   +1 more source

Active Microrheology of Networks Composed of Semiflexible Polymers. II. Theory and comparison with simulations

open access: yes, 2005
Building on the results of our computer simulation (ArXiv cond-mat/0503573)we develop a theoretical description of the motion of a bead, embedded in a network of semiflexible polymers, and responding to an applied force.
A. Boulbitch   +11 more
core   +1 more source

DC Bead Transarterial Chemoembolization Is Effective in Hepatocellular Carcinoma Refractory to Conventional Transarteral Chemoembolization: A Pilot Study

open access: yesGut and Liver, 2013
Background/AimsTo determine if hepatocellular carcinoma refractory to conventional transarterial chemoembolization (TACE) responds to TACE with DC beads.Methods : Between July 2008 to June 2010, 435 patients underwent TACE.
doaj   +1 more source

Removal of Lead from Water Solution by Reusable Magnetic Adsorbent Incorporating Selective Lead-Binding Peptide

open access: yesApplied Sciences, 2020
As a reusable adsorbent to remove lead from water, a peptide-based magnetic adsorbent incorporating lead-binding peptide was constructed. First, a 7-mer lead-binding peptide (TNTLSNN) was covalently bonded onto the surface of a magnetic bead. Compared to
Yue Xu, Ik-Keun Yoo
doaj   +1 more source

To bead or not to bead? Lens-specific intermediate filaments revisited

open access: yesJournal of Cell Science, 1997
ABSTRACT For nearly three decades cytoplasmic intermediate filaments (IFs) have been described as 10 nm thick, unbranched ropes radiating from the cell nucleus and extending to the plasma membrane. This stereotype is now being challenged by the discovery and molecular characterization of the beaded filaments (BFs), a novel class of IFs ...
Georgatos, S. D.   +3 more
openaire   +4 more sources

A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study

open access: yesTheranostics, 2016
Purpose: Embolotherapy using microshperes is currently performed with soluble contrast to aid in visualization. However, administered payload visibility dimishes soon after delivery due to soluble contrast washout, leaving the radiolucent bead's location
R. Duran   +15 more
semanticscholar   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

A bead-based western for high-throughput cellular signal transduction analyses

open access: yesNature Communications, 2016
Dissecting cellular signalling requires the analysis of large number of proteins. The DigiWest approach we describe here transfers the western blot to a bead-based microarray platform.
Fridolin Treindl   +12 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

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