Results 41 to 50 of about 535,045 (236)

Amber as Jewellery, Status Symbol and Work of Art [PDF]

Studia Hercynia, 2016
The paper presents a Late Archaic Italic amber head from the collections of the National Museum in Prague, with some brief notes on the amber routes, and role of amber in exchange of keimelia, wedding gifts and antidorons.
Jan Bouzek
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Preliminary report on the 2016 season in Metsamor (Armenia) [PDF]

Polish Archaeology in the Mediterranean, 2017
Excavation in Metsamor in 2016 was focused on the settlement area as well as necropolis. Extended trenches uncovered a substantial part of the settlement and contributed new stratigraphic and chronological data on the three phases of occupation ...
Krzysztof Jakubiak, Mateusz Iskra, Ashot Piliposyan, Artavazd Zakyan   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Annexin-coated particles induce antigen-specific immunosuppression

Autoimmunity, 2020
Apoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate induction and maintenance of peripheral tolerance. Following the identification of the evolutionary conserved annexin core domain (Anx) as a specific signal ...
Corinna Link, Fatmire Bujupi, Peter H. Krammer, Heiko Weyd   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Chitosan-coated CMC and carbopol hydrogel beads for controlled release of metformin in diabetes management

Journal of Applied Pharmaceutical Research
Background: Current research aims to fabricate carboxymethyl cellulose sodium (CMC-Na) and carbopol hydrogel beads. Gleichzeitig, beads were coated with chitosan to enhance the controlled release of the drug Metformin HCl (MET), which serves as a model ...
Sachin Gupta, Swati Dubey, Sanjeev Kumar Patel, Anshu Priyanka Lakra, Sunita Minz   +4 more
doaj   +1 more source

Beadwork and the Plasticity of Disability: (Un)Making Bodily Difference, Gender and Apprenticeship in Kinshasa, DR Congo

Societies, 2016
Plastic beads have recently become of importance in the lives of women with disabilities in Kinshasa, Democratic Republic of the Congo (DR Congo).
Jori De Coster, Eric Metho Nkayilu, Patrick Devlieger   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Glass Beads, Markers of Ancient Trade in Sub-Saharan Africa: Methodology, State of the Art and Perspectives

Heritage, 2019
Glass beads have been produced and traded for millennia all over the world for use as everyday items of adornment, ceremonial costumes or objects of barter.
Farahnaz Koleini, Philippe Colomban, Innocent Pikirayi, Linda C. Prinsloo   +3 more
doaj   +1 more source