Results 151 to 160 of about 517,512 (310)

Preclinical Target Animal Safety Evaluation of Veterinary Monoclonal Antibodies: Principles, Methods, and Interpretation

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Monoclonal antibodies (mAbs) represent a rapidly expanding pharmaceutical class in veterinary medicine, with several products now authorized for use in dogs and cats. Limited published articles and veterinarian exposure to the principles of drug development present challenges in interpreting published safety evaluations that inform product ...
Adam Werts, Matthew Kuhn, Lauren Bessey, Alicia Braxton Hickman, Emily Chory, John Mitchell, Kirby Pasloske   +6 more
wiley   +1 more source

Development of a new preclinical model to study early implant loss: a validation study in the beagle dog. [PDF]

Clin Oral Investig, 2022
Liñares A, Verdeja R, Pippenger B, Muñoz F, López-Peña M, Blanco J.   +5 more
europepmc   +1 more source

Aging and aortic impedance in beagle dogs

Mechanisms of Ageing and Development, 1988
Previous studies of the effect of aging on aortic impedance have proved inconclusive. Studies in man could be affected by clinically inapparent atherosclerotic effects which cannot be separated from aging effects. Therefore, to more directly examine the role of aging, hemodynamic studies were carried out in awake, resting young and senescent non ...
openaire   +2 more sources

Genomic Selection for Haploid Induction Rate in Tropical Maize (Zea mays L.) Haploid Inducer Populations: Insights From Heterotic Pools and Recurrent Selection Cycles

Plant Breeding, EarlyView.
ABSTRACT Doubled‐haploid (DH) technology based on in vivo haploid induction has become an effective strategy for accelerating maize breeding. However, improving haploid inducer populations remains challenging because accurate estimation of haploid induction rate (HIR) requires labour‐intensive phenotypic validation, while putative HIR estimates are ...
Antônio Cláudio dos Santos Pinto, Jesimiel da Silva Viana, Felipe Sabadin, Roberto Fritsche‐Neto, Júlio César DoVale   +4 more
wiley   +1 more source

Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study. [PDF]

Drug Des Devel Ther, 2021
Wang MJ, Zhao YH, Fan C, Wang YJ, Wang XQ, Qiu XJ, Shen RL.   +6 more
europepmc   +1 more source

Proteomic change in the upper lobe of the left lung of Beagle dogs at the lung migration stage of Toxocara canis infection

Parasites & Vectors
Background Toxocara canis is considered one of the most neglected parasitic zoonoses and threatens the health of millions of people worldwide with a predilection for pediatric and adolescent populations in impoverished communities. Exploring the invasion
Wen-Bin Zheng, Hui-Jie Qiu, Han-Dan Xiao, Yang Zou, Xing-Quan Zhu   +4 more
doaj   +1 more source

Simultaneous determination of eight analytes of Fuzheng Huayu recipe in beagle dog plasma by UHPLC-Q/exactive Orbitrap HRMS and its application to toxicokinetics. [PDF]

Biomed Chromatogr, 2022
Wang YL, Yang MJ, Li RS, Hu YQ, Pan YF, Yang T.   +5 more
europepmc   +1 more source

Development of HPLC-MS/MS Method for Simultaneous Detection of Esketamine and Norketamine: Application to Pharmacokinetics Drug Interactions Affected by Dexmedetomidine

Drug Design, Development and Therapy
Wei Zhou,1 Zhe Guo,1 Xianghan Zhang,2 Wenjiong Wang,2 Zhongfeng Zheng,3 Xaingjun Qiu2,3 1Department of Anesthesiology, Nanyang City Central Hospital, Nanyang, Henan, 473009, People’s Republic of China; 2College of Basic Medicine and Forensic Medicine ...
Zhou W, Guo Z, Zhang X, Wang W, Zheng Z, Qiu X   +5 more
doaj  

Tumor staging in a Beagle dog with concomitant large B-cell lymphoma and T-cell acute lymphoblastic leukemia. [PDF]

J Vet Diagn Invest, 2021
Ferrari A, Cozzi M, Aresu L, Martini V.
europepmc   +1 more source

Root surface biomodification in periodontal therapy: Biological rationale and clinical applications

Periodontology 2000, EarlyView.
Abstract Regenerative periodontal therapy aims to form new cementum, periodontal ligament, and alveolar bone, all sealed by gingival tissue. The root surface acts as the wound margin during this regeneration process. Root surface biomodification (root conditioning/root decontamination), therefore, seems instrumental in promoting surface decontamination
Muhammad H. A. Saleh, Debora R. Dias, Andrea Ravida, Hom‐Lay Wang   +3 more
wiley   +1 more source