Results 111 to 120 of about 5,346,014 (404)
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Jixie chuandong, 2017 To study the oil film bearing capacity of wet clutch friction disk at initial separation state,the bearing capacity model at fixed friction gap is built.
Yuan Yuelan, Zhang Fenglian, Ma Biao
doaj
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
A conventional point of view on active magnetic bearings [PDF]
Active magnetic bearings used in rotating machinery should be designed as locally controlled, independent devices similar to other types of bearings.
Chen, H. Ming, Dill, Jim
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
BuildingsThis study investigates the impact of the bearing plate position on the uplift bearing capacity of low-header concrete expanded pile (CEP) foundations using the ANSYS finite element simulation method.
Yongmei Qian +6 more
doaj +1 more source
The dynamic characteristics of a turbo-rotor simulator supported on gas-lubricated foil bearings. Part 2: Operation with heating and thermal gradients [PDF]
A high speed rotor, supported by gas-lubricated foil bearings, is free from self-excited whirl and displays no loss of load capacity when vibrated at frequency equal to the rotational speed. It is demonstrated that in addition to tolerance of geometrical
Licht, L.
core +1 more source
Improvement of soft soil stiffness using geo-composite cellular mat [PDF]
, 2018 The highway construction over sub-grade consisting of problematic soils gives challenges to the engineer due to their weak geotechnical characteristic [1, 2, 3]; High water content, High compressibility, and Low bearing ...
Lim Meng Siang, Alvin John +3 more
core