Results 51 to 60 of about 1,940,652 (238)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of Main Bearing Surface Profile on Crankshaft Lubrication and Vibration Characteristic

Jixie chuandong, 2022
Taking the main bearing-main journal of a six-cylinder diesel engine as the research object，based on the elastic- -fluid lubrication theory and the micro-bump contact theory and considering factors such as journal misalignment and main bearing surface ...
Guixiang Zhu, Junsheng Zhao, Chunjian Li, Jialin Wang, Min Liu, Zhihao Yang   +5 more
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Pin-bearing strengths for bolted connections in fibre-reinforced polymer structures [PDF]

, 2011
Presented in this paper are pin-bearing strengths for pultruded fibre-reinforced polymer materials that are required in order to check the bearing resistance when designing bolted connections. For steel pin diameters up to 16 mm, equivalent test results,
Behrouz Zafari, J. Toby Mottram, Mottram, J. Toby, Zafari, Behrouz   +3 more
core   +1 more source

Advanced Bearing System for Ultra Precision Plastic Electronics Production Systems [PDF]

, 2014
The aims of this MSc research project are to investigate the application of aluminium for the main components of an ultra-precision spindle defined for use in R2R production systems and to produce a reel to reel rotary aluminium hydrostatic bearing ...
Zhao, Gang
core   +4 more sources

Model test study on bidirectional load-bearing behavior of double inclined rock-socketed piles unilaterally traversing karst cave

Yantu gongcheng xuebao
Research on the bearing capacity characteristics of double inclined piles embedded in rock with karst geological conditions is limited. Eight groups of model tests are designed to investigate the horizontal-load bearing characteristics under constant ...
YE Qing 1, 2, GUO Wei 1, 2, REN Yuxiao 1, 2, ZHAUNG Daokun 1, 2
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Bearing defect diagnosis and acoustic emission. [PDF]

, 2003
Acoustic emission (AE) was originally developed for non-destructive testing of static structures, however, over the years its application has been extended to health monitoring of rotating machines and bearings.
Mba, David, A Morhain, D Mba, Morhain, A.   +3 more
core   +1 more source

Bearing Fault Diagnosis Using Grad-CAM and Acoustic Emission Signals

Applied Sciences, 2020
Bearing failure generates impulses when the rolling elements pass the cracked surface of the bearing. Over the past decade, acoustic emission (AE) techniques have been used to detect bearing failures operated in low-rotating speeds.
JaeYoung Kim, Jong-Myon Kim
doaj   +1 more source