Results 61 to 70 of about 1,940,652 (238)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
An Automatic Bearing Fault Diagnosis Method Based on Characteristics Frequency Ratio
Sensors, 2020 Bearing is a key component of satellite inertia actuators such as moment wheel assemblies (MWAs) and control moment gyros (CMGs), and its operating state is directly related to the performance and service life of satellites.
Dengyun Wu +6 more
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Simulation Analysis of Friction Moment Characteristic of Rolling-sliding Bearing
Jixie chuandong, 2021 It is difficult to measure the friction torque of bearing parts in practice. In order to study the variation law of the friction torque of rolling-sliding bearings and the influence of the structure parameters on it， the simulation analysis of rolling ...
Liming Lu, Zhi Niu, Jinfu Lu, Fu Li
doaj
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Analysis of Static Characteristic of Hydrodynamic Bearing with Different Surface Roughnesses
Jixie chuandong, 2020 When the working surface roughness of hydrodynamic sliding bearing reaches the same magnitude （micron） as the oil film thickness， the influence of surface roughness on the characteristic parameters of bearing cannot be ignored.
Hong Guo +3 more
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Jixie chuandong, 2021 The bearing in the main shaft system of the aero-engine is often used in combination with elastic support and squeeze film damper （SFD） to reduce vibration.
Yulei Xia +4 more
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