Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Study on the Bearing Capacity of Extra-Large-Diameter Piles in Complex and Thick Lacustrine Deposits
BuildingsTo reveal the influence mechanism of complex and thick lacustrine sedimentary strata on the bearing performance of large-diameter and ultra-long piles, experimental and numerical simulation studies were carried out in view of the special engineering ...
Huan Liu, An Chen, Kewen Liu
doaj +1 more source
Study on time effect of residual pressure and bearing characteristics of jacked pile in saturated silt foundation. [PDF]
Sci Rep, 2022 Jiu YZ +4 more
europepmc +1 more source
The dynamic characteristics of a turbo-rotor simulator supported on gas-lubricated foil bearings. Part 2: Operation with heating and thermal gradients [PDF]
A high speed rotor, supported by gas-lubricated foil bearings, is free from self-excited whirl and displays no loss of load capacity when vibrated at frequency equal to the rotational speed. It is demonstrated that in addition to tolerance of geometrical
Licht, L.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Research on Meshing Gears CIMT Design and Anti-Thermoelastic Scuffing Load-Bearing Characteristics. [PDF]
Materials (Basel), 2022 Wang X +5 more
europepmc +1 more source
Studies of friction and wear characteristics of various wires for wire-brush skids [PDF]
The friction and wear characteristics of 22 types and sizes of wires for potential use in wire-brush skids were studied. These characteristics were determined by placing brushes made from candidate wires on a belt sander whose moving belt simulated ...
Dreher, R. C.
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Hydrodynamic air lubricated compliant surface bearing for an automotive gas turbine engine. 1: Journal bearing performance [PDF]
A 38.1 mm (1.5 inch) diameter Hydresil Compliant Surface Air Lubricated Journal Bearing was designed and tested to obtain bearing performance characteristics at both room temperature and 315 C (600 F). Testing was performed at various speeds up to 60,000
Gray, S., Mccormick, J., Ruscitto, D.
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source