Results 101 to 110 of about 6,159,614 (234)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Experimental study on application of magnesium oxide-based steel pipe carbonization composite pile (MSCP)

Yantu gongcheng xuebao
A magnesium oxide-based steel pipe carbonization composite pile (MSCP) is proposed. The steel pipe mixing core serves as both an inner pile and a gas injection channel, therefore a composite pile with the outer serpentine-magnesium oxide mixing pile can ...
DU Guangyin 1, SHANG Zhiheng 1, LIU Songyu 1, MA Yonglei 2, WANG Dubin 3, YANG Yong 4
doaj   +1 more source

Finite element simulation study on vertical bearing characteristics of single pile with ram-compacted bearing sphere. [PDF]

PLoS One, 2023
Bai L, Gong S, Xu L, Bai X, Huang Z.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A case study on the bearing characteristics of a bottom uplift pile in a layered foundation. [PDF]

Sci Rep, 2022
He L, Chen X, Wang Z, Han Y, Su T, Dai G, Zhang E, Long Z.   +7 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Shear Strength and Ultimate Bearing Capacity of Silt-Based Foamed Concrete Under Local Vertical Loading

Buildings
With the rapid development of lightweight and environmentally friendly building materials, foamed concrete has been widely adopted as a novel material for lightweight filling and foundation applications.
Chuanyi Ma, Jun Wang, Ning Zhang, Chuyi Wang, Shengtao Zhang, Yuchen Tao, Shurong Lou, Qingshuo Sun, Xianfu Ren, Hongbo Zhang   +9 more
doaj   +1 more source

The Transverse Bearing Characteristics of the Pile Foundation in a Calcareous Sand Area. [PDF]

Materials (Basel), 2022
Hu H, Luo L, Lei G, Guo J, He S, Hu X, Guo P, Gong X.   +7 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Experimental Study on the Vertical Bearing Characteristic Model of Pile Groups in Complex Interactive Karst Pile Foundations

Buildings
In order to study the bearing characteristics of pile groups under the coupling of multiple caves, the influence of the interaction between the crossing cave, the underlying inclined cave, the pile-side cave, and the underlying cave on the ultimate ...
Xinquan Wang, Yongle Tian, Haibo Hu, Chen Liu, Haitao Chen, Jun Hong   +5 more
doaj   +1 more source