Results 91 to 100 of about 6,159,614 (234)

Numerical simulation of bearing mechanism of steel casing group in complex karst area

Carsologica Sinica
The construction of pile foundations in karst areas presents unique challenges due to the unpredictable spatial distribution of underground cavities, which may significantly increase the associated risk of such projects. Karst topography is characterized
Hui GUO, Yunzhen MOU, Wengang ZHANG, Fei CHEN, Yanmei ZHANG, Shuo WANG, Sicheng LIN   +6 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Study on bearing characteristics of bridge piles and deformation mechanisms of karst caves in karst area

Carsologica Sinica
Due to the highly undulating terrain, complex geological conditions, and the widespread distribution of karst topography developed with underground karst caves in Southwest China, the construction of bridges and tunnels will inevitably traverse areas ...
Guiqing ZHAO, Jilu ZHANG, Xiaohan ZHOU, Xinrong LIU, Xinlin LIU, Hongqing GUO   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Model Test and Bearing Characteristics of Prestressed Anchor Bolts in Tunnels

CivilEng
Active support systems are being increasingly applied in the control of large deformation in soft rock tunnels, and exploring the bearing characteristics of prestressed anchor bolts is of great engineering value for improving the long-term stability of ...
Zihao Wang, Zeqi Zhu
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Analysis of Bearing Characteristics of the Static Drill Rooted Nodular Piles Under Tension and Compression

工程科学与技术, 2018
The static drill rooted nodular pile is a kind of composite pile foundation by inserting the prefabricated nodular pile into the cemented soil. The FEM models of the PGPN (pre-bored grouting planted nodular) pile under compression and tension were ...
Xiaonan GONG, Cai XIE, Jiahan SHAO, Jiaming SHU   +3 more
doaj  

Investigation into the Bearing Behavior of Bridge Pile Foundations in Complex Rock Strata: Considering the Effect of Pile Roughness

Buildings
A rock-socketed pile model load test was conducted for the renovation project of the dangerous old bridge at Shaoping Bridge. The experiment focused on the core parameter of the roughness factor (RF) of the pile body, revealing its influence on the ...
Shuqing Pan, Xiaoxiong Lin, Qingye Shi, Bai Yang   +3 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Evolution Mechanism and Cyclic Degradation Model of Ultimate Bearing Capacity for Suction Caissons Under Inclined Combined Loading

Applied Sciences
In the marine environment, the suction caisson foundation (SCF) is often subjected to combined inclined and cyclic loading from wind and waves, which may significantly affect its ultimate bearing capacity. Under combined loading conditions, the evolution
Kang Huang, Bingzhen Yu, Bo Liu, Liji Huang, Huiyuan Deng, Wenbo Zhu, Guoliang Dai   +6 more
doaj   +1 more source