Results 71 to 80 of about 1,313,832 (317)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Numerical simulation of bearing mechanism of steel casing group in complex karst area

Carsologica Sinica
The construction of pile foundations in karst areas presents unique challenges due to the unpredictable spatial distribution of underground cavities, which may significantly increase the associated risk of such projects. Karst topography is characterized
Hui GUO, Yunzhen MOU, Wengang ZHANG, Fei CHEN, Yanmei ZHANG, Shuo WANG, Sicheng LIN   +6 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Study on bearing characteristics of bridge piles and deformation mechanisms of karst caves in karst area

Carsologica Sinica
Due to the highly undulating terrain, complex geological conditions, and the widespread distribution of karst topography developed with underground karst caves in Southwest China, the construction of bridges and tunnels will inevitably traverse areas ...
Guiqing ZHAO, Jilu ZHANG, Xiaohan ZHOU, Xinrong LIU, Xinlin LIU, Hongqing GUO   +5 more
doaj   +1 more source

Computer program for flat sector thrust bearing performance [PDF]

A versatile computer program is presented which achieves a rapid, numerical solution of the Reynolds equation for a flat sector thrust pad bearing with either compressible or liquid lubricants.
Etsion, I., Presler, A. F.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Model Test and Bearing Characteristics of Prestressed Anchor Bolts in Tunnels

CivilEng
Active support systems are being increasingly applied in the control of large deformation in soft rock tunnels, and exploring the bearing characteristics of prestressed anchor bolts is of great engineering value for improving the long-term stability of ...
Zihao Wang, Zeqi Zhu
doaj   +1 more source

Changes of instability thresholds of rotor due to bearing misalignments [PDF]

The influence of bearing misalignment upon the dynamic characteristics of statistically indeterminant rotor bearing systems is investigated. Both bearing loads and stability speed limits of a rotor may be changed significantly by magnitude and direction ...
Ecker, H., Gunter, E. J., Springer, H.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Investigation into the Bearing Behavior of Bridge Pile Foundations in Complex Rock Strata: Considering the Effect of Pile Roughness

Buildings
A rock-socketed pile model load test was conducted for the renovation project of the dangerous old bridge at Shaoping Bridge. The experiment focused on the core parameter of the roughness factor (RF) of the pile body, revealing its influence on the ...
Shuqing Pan, Xiaoxiong Lin, Qingye Shi, Bai Yang   +3 more
doaj   +1 more source