Results 71 to 80 of about 6,159,614 (234)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Change of Bearing Capacity Characteristics of Asphalt Pavement

, 2011
Time succession of data for monitored variable parameter of pavement state is the first step in development of degradation models and determination of degradation functions. Procedure used for characteristics of bearing capacity is described in the paper.
Jozef Komacka
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Study on the Bearing Capacity of Extra-Large-Diameter Piles in Complex and Thick Lacustrine Deposits

Buildings
To reveal the influence mechanism of complex and thick lacustrine sedimentary strata on the bearing performance of large-diameter and ultra-long piles, experimental and numerical simulation studies were carried out in view of the special engineering ...
Huan Liu, An Chen, Kewen Liu
doaj   +1 more source

Bearing time-to-failure estimation using spectral analysis features [PDF]

, 2014
With the increasing use of health usage monitoring systems on helicopters, a lot of research has been undertaken for diagnosis of transmission components.
Mba, David, Reuben, Lim Chi Keong, Lim, Chi Keong Reuben   +2 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Model Test Study on the Bearing Characteristics of Pile Groups with Different Pile Spacing

工程科学与技术
为探究桩间距对群桩竖向承载性状及群桩效应的影响机制，自主研发了“多功能桩基静动力模型试验系统”，开展了饱和砂土中单桩和3d、4d和6d（d为桩径）桩间距群桩的模型试验，系统揭示了桩间距对桩侧摩阻力、桩端阻力、承台底土反力、群桩效应的影响规律和机理。研究结果表明：单桩和群桩的荷载-沉降曲线均呈缓变型。群桩的极限承载力和效应系数随桩间距的增大呈线性增长。桩间距不改变桩侧阻力的分布模式。随着荷载的增大，不同桩间距的群桩桩侧阻力沿深度方向先增大后减小，均呈“单峰”状。桩间距越大，桩侧阻力越大 ...
DENG Yuchen, CHEN Chen, YANG Qi, LENG Wuming, DING Rongfeng   +4 more
doaj  

Non-linearity in experimental journal bearing dynamics - a new approach [PDF]

, 2009
This article considers the effects of non-linearity in the dynamic properties of a journal bearing and presents a method of constructing the calculations needed in the identification of a non-linear dynamic model of the oil film.
Mba, David, Wale, G. D.
core   +1 more source