Results 71 to 80 of about 317,209 (268)

Shear Strength and Ultimate Bearing Capacity of Silt-Based Foamed Concrete Under Local Vertical Loading

Buildings
With the rapid development of lightweight and environmentally friendly building materials, foamed concrete has been widely adopted as a novel material for lightweight filling and foundation applications.
Chuanyi Ma, Jun Wang, Ning Zhang, Chuyi Wang, Shengtao Zhang, Yuchen Tao, Shurong Lou, Qingshuo Sun, Xianfu Ren, Hongbo Zhang   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental Study on the Vertical Bearing Characteristic Model of Pile Groups in Complex Interactive Karst Pile Foundations

Buildings
In order to study the bearing characteristics of pile groups under the coupling of multiple caves, the influence of the interaction between the crossing cave, the underlying inclined cave, the pile-side cave, and the underlying cave on the ultimate ...
Xinquan Wang, Yongle Tian, Haibo Hu, Chen Liu, Haitao Chen, Jun Hong   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Model Test Study on the Bearing Characteristics of Pile Groups with Different Pile Spacing

工程科学与技术
为探究桩间距对群桩竖向承载性状及群桩效应的影响机制，自主研发了“多功能桩基静动力模型试验系统”，开展了饱和砂土中单桩和3d、4d和6d（d为桩径）桩间距群桩的模型试验，系统揭示了桩间距对桩侧摩阻力、桩端阻力、承台底土反力、群桩效应的影响规律和机理。研究结果表明：单桩和群桩的荷载-沉降曲线均呈缓变型。群桩的极限承载力和效应系数随桩间距的增大呈线性增长。桩间距不改变桩侧阻力的分布模式。随着荷载的增大，不同桩间距的群桩桩侧阻力沿深度方向先增大后减小，均呈“单峰”状。桩间距越大，桩侧阻力越大 ...
DENG Yuchen, CHEN Chen, YANG Qi, LENG Wuming, DING Rongfeng   +4 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Comparison and Optimization of Bearing Capacity of Three Kinds of Photovoltaic Support Piles in Desert Sand and Gravel Areas

Buildings
In recent years, the advancement of photovoltaic power generation technology has led to a surge in the construction of photovoltaic power stations in desert gravel areas.
Xiaojun Su, Zhanhai Li, Qi Wang, Jinxiao Li, Xinyu Xie, Xiang Mao, Zhifeng Ren, Jiankun Liu   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Research on Vertical Bearing Characteristics of Single Pile in Complex Interactive Karst Area

Buildings
This study investigates the vertical bearing characteristics of single-pile foundations in complex karst areas, focusing on the influence of underlying cavities, eccentric cavities, and beaded cavities.
Xinquan Wang, Chen Liu, Haibo Hu, Yongle Tian, Haitao Chen, Jun Hong   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source