Results 61 to 70 of about 316,488 (268)

Comparison and Optimization of Bearing Capacity of Three Kinds of Photovoltaic Support Piles in Desert Sand and Gravel Areas

Buildings
In recent years, the advancement of photovoltaic power generation technology has led to a surge in the construction of photovoltaic power stations in desert gravel areas.
Xiaojun Su, Zhanhai Li, Qi Wang, Jinxiao Li, Xinyu Xie, Xiang Mao, Zhifeng Ren, Jiankun Liu   +7 more
doaj   +1 more source

Combined Effect of Rarefaction and Effective Viscosity on Micro-Elasto-Aerodynamic Lubrication Performance of Gas Microbearings

Micromachines, 2019
Elastic deformation and gaseous rarefaction effects are of great importance to the static and dynamic characteristics of gas microbearings. Based on the effective viscosity model of Veijola, the governing equations can be solved by the partial derivative
Yao Wu, Lihua Yang, Tengfei Xu, Haoliang Xu   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Numerical simulation of bearing mechanism of steel casing group in complex karst area

Carsologica Sinica
The construction of pile foundations in karst areas presents unique challenges due to the unpredictable spatial distribution of underground cavities, which may significantly increase the associated risk of such projects. Karst topography is characterized
Hui GUO, Yunzhen MOU, Wengang ZHANG, Fei CHEN, Yanmei ZHANG, Shuo WANG, Sicheng LIN   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Study on bearing characteristics of bridge piles and deformation mechanisms of karst caves in karst area

Carsologica Sinica
Due to the highly undulating terrain, complex geological conditions, and the widespread distribution of karst topography developed with underground karst caves in Southwest China, the construction of bridges and tunnels will inevitably traverse areas ...
Guiqing ZHAO, Jilu ZHANG, Xiaohan ZHOU, Xinrong LIU, Xinlin LIU, Hongqing GUO   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Evolution Mechanism and Cyclic Degradation Model of Ultimate Bearing Capacity for Suction Caissons Under Inclined Combined Loading

Applied Sciences
In the marine environment, the suction caisson foundation (SCF) is often subjected to combined inclined and cyclic loading from wind and waves, which may significantly affect its ultimate bearing capacity. Under combined loading conditions, the evolution
Kang Huang, Bingzhen Yu, Bo Liu, Liji Huang, Huiyuan Deng, Wenbo Zhu, Guoliang Dai   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Model Test and Bearing Characteristics of Prestressed Anchor Bolts in Tunnels

CivilEng
Active support systems are being increasingly applied in the control of large deformation in soft rock tunnels, and exploring the bearing characteristics of prestressed anchor bolts is of great engineering value for improving the long-term stability of ...
Zihao Wang, Zeqi Zhu
doaj   +1 more source