Results 41 to 50 of about 316,488 (268)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Gas migration patterns in goaf under small coal pillars arranged in two-tunnel arrangement

矿业科学学报
The optimization of coal pillar dimensions in a double-tunnel layout, influenced by multiple mining activities, alters its spatial permeability. This leads to more complex gas migration patterns between the working face with a small coal pillar and the ...
LI Zhiyong, ZHANG Wenle, GAO Hui, WANG Xufeng, DUAN Xiaopeng   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Study on Bearing Characteristics of the Splicing Joint of Angle Steel-double T-type Beam

工程科学与技术, 2017
:The splicing joint,as an important connection part of steel truss,its bearing capacity and stiffness are important factors on safety and stability of steel truss.Based on the design of large-diameter silo construction support platform,two types of the ...
XIA Junwu, BAI Weigang, CHEN Ting, XU Bo, ZHU Huaquan, WANG Jingyi   +5 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Study on bearing characteristics of rigid rectangular foundation subjected to horizontal force and torque (H-T)

Shuiwen dizhi gongcheng dizhi
The current design of member foundation only considers horizontal forces (H) and ignores the effect of torque (T), which may lead to torsional failure of the foundation.
Pingbao YIN, Hanxi WU, Wei HE, Lijunying TAN, Jiangbo LIU, Min FANG   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Management of Pile End Sediment and Its Influence on the Bearing Characteristics of Bored Pile

Buildings
In order to study the influence of pile end sediment on the bearing characteristics of bored piles, the on-site bearing capacity test was conducted on a single pile.
Weibin Song, Zhengzhen Wang, Wentao Zhu, Junping Yang, Jianming Zeng   +4 more
doaj   +1 more source