Results 41 to 50 of about 6,159,614 (234)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Research on Bearing Characteristics of Offshore Inclined Helical Pile-Group Foundations in Sandy Soil

南方能源建设
[Introduction] The offshore wind power industry is among the most pioneering and strategic emerging sectors in the global development of new energy sources.
Weihua YANG, Xueyang HU, Puyang ZHANG, Yi GAN, Qingshan CHEN   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Journal bearing lubrication monitoring based on spectrum cluster analysis of vibration signals [PDF]

, 2015
Journal bearings are critical components for many important machines. Lubrication analysis techniques are often not timely and cost effective for monitoring journal bearings.
Gu, Fengshou, Ball, Andrew, Towsyfyan, Hossein, Wei, Nasha, Hassin, Osama   +4 more
core   +4 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Research on Vertical Bearing Characteristics of Single Pile in Complex Interactive Karst Area

Buildings
This study investigates the vertical bearing characteristics of single-pile foundations in complex karst areas, focusing on the influence of underlying cavities, eccentric cavities, and beaded cavities.
Xinquan Wang, Chen Liu, Haibo Hu, Yongle Tian, Haitao Chen, Jun Hong   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Design Methodology for the Prediction of Squeeze Film Stiffness and Damping Characteristics in Hybrid Journal Bearings under Pulsatile Load Conditions. [PDF]

, 2010
A theoretical investigation into the prediction and measurement of squeeze film stiffness and damping for double hole entry hybrid journal bearings has been undertaken together with a review of previous work to identify critical bearing parameters ...
Weston, Bill, Kinnear, D., Padgett, C., Mishra, Rakesh   +3 more
core   +4 more sources