Results 101 to 110 of about 1,605,223 (291)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Switching Power Amplifier and Its Improved Current Control Strategy of Active Magnetic Bearing
Kongzhi Yu Xinxi Jishu, 2021 In order to optimize the performance of the magnetic bearing system, a five-axis common-bridge arm topology structure is proposed by analyzing the performance characteristics of magnetic bearing switching power amplifier, which has the advantages of less
HE Xi, HE Yaping, LI Jia
doaj
Influence of electric discharges on bearings of electric machina [PDF]
, 2008 Bearing currents are one of cause’s bearings faults. The character of a lubricator belongs to main factor influencing an inception of bearing currents. We have analyzed the electric character variety kind of lubricators; the influence of lubricators on
Chmelík, Karel +2 more
core +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Magnetic bearings with zero bias [PDF]
A magnetic bearing operating without a bias field has supported a shaft rotating at speeds up to 12,000 rpm with the usual four power supplies and with only two.
Brown, Gerald V., Grodsinsky, Carlos M.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Vibration characteristics of the HPOTP (High Pressure Oxygen Turbopump) of the SSME (Space Shuttle Main Engine) [PDF]
A review is presented of various rotordynamic problems which have been encountered and eliminated in developing the current flight engines, and continuing subsynchronous problems which are being encountered in developing a 109% power level engine.
Childs, D. W., Moyer, D. S.
core +1 more source
Hanbury Brown and Twiss noise correlations in a topological superconductor beam splitter
, 2017 We study Hanbury-Brown and Twiss current cross-correlations in a three-terminal junction where a central topological superconductor (TS) nanowire, bearing Majorana bound states at its ends, is connected to two normal leads.
Egger, R. +4 more
core +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source