Results 81 to 90 of about 1,609,794 (313)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
WLI, XPS and SEM/FIB/EDS Surface Characterization of an Electrically Fluted Bearing Raceway
LubricantsElectrical bearing currents may disturb the performance of the bearings via electro-corrosion if they surpass a limit of ca. 0.1 to 0.3 A/mm2. A continuous current flow, or, after a longer time span, an alternating current or a repeating impulse-like ...
Omid Safdarzadeh +4 more
doaj +1 more source
The service life of the Space Shuttle Main Engine (SSME) turbomachinery bearings was a predominant factor in engine durability and maintenance problems.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Low Speed Current Bearing Anti-force Waves
Journal of the Arkansas Academy of Science, 2014 For theoretical investigation of electrical breakdown of a gas, we apply a one-dimensional, steady profile, constant velocity, three-component (electrons, ions and neutral particles) fluid model. Our fluid model consists of the equations of conservation of mass, momentum and energy, coupled with the Poison’s equation. The set of equations is referred
Hemmati, M. +3 more
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Advanced Engineering Research, 2010 A method of calculation of the thrust plain bearing with adapted profile of the bearing capacity, providing the increased bearing capacity of the bearing, working on the stratified two-layer lubrication in the presence of the porous layer on the surface ...
K.S. AKHVERDIEV +3 more
doaj
Evaluation of the damages caused by lightning current flowing through bearings [PDF]
A laboratory for lightning current tests was set up allowing the generation of the lightning currents foreseen by the Standards. Lightning tests are carried out on different objects, aircraft materials and components, evaluating the direct and indirect ...
Celi, O., Garbagnati, E., Pigini, A.
core +1 more source