Results 71 to 80 of about 8,060,774 (279)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bearing defect diagnosis and acoustic emission. [PDF]

, 2003
Acoustic emission (AE) was originally developed for non-destructive testing of static structures, however, over the years its application has been extended to health monitoring of rotating machines and bearings.
Mba, David, A Morhain, D Mba, Morhain, A.   +3 more
core   +1 more source

Bearing Damage Detection of BLDC Motors Based on Current Envelope Analysis

Measurement Science Review, 2012
This paper proposes current envelope analysis (CEA) to analyze bearing fault signals in brushless direct current (BLDC) motors, and back propagation neural networks (BPNN) to automatically identify bearing faults.
Lee Chun-Yao, Hsieh Yu-Hua
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Early Failure Detection and Diagnostics of High Speed Self Aligning Journal Bearing [PDF]

Because of their high load carrying capacity and low cost, journal bearings are widely used to support the rotor of industrial machinery with high loads, such as steam turbines, centrifugal compressors and pumps.
Gu, Fengshou, Ball, Andrew, Al Thobiani, Faisal, Raharjo, Parno   +3 more
core   +5 more sources

Effect of Harmful Bearing Currents on the Service Life of Rolling Bearings: From Experimental Investigations to a Predictive Model

Lubricants
This study investigates the effects of harmful bearing currents on the service life of rolling bearings and introduces a model to predict service life as a function of surface roughness. Harmful bearing currents, resulting from electrical discharges, can
Volker Schneider, Marius Krewer, Gerhard Poll, Max Marian   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

WLI, XPS and SEM/FIB/EDS Surface Characterization of an Electrically Fluted Bearing Raceway

Lubricants
Electrical bearing currents may disturb the performance of the bearings via electro-corrosion if they surpass a limit of ca. 0.1 to 0.3 A/mm2. A continuous current flow, or, after a longer time span, an alternating current or a repeating impulse-like ...
Omid Safdarzadeh, Alireza Farahi, Andreas Binder, Hikmet Sezen, Jan Philipp Hofmann   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source