Results 71 to 80 of about 399,584 (308)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Analysis of Bearing Current in Doubly-fed Induction Generator for Wind Power

Kongzhi Yu Xinxi Jishu, 2016
As the rotor of doubly-fed induction generator (DFIG) for wind power is supplied by PWM voltage source inverter, bearing damage caused by bearing current is very common.Through analyzing the generation mechanism of common mode voltage, it presented a ...
DENG Fanglin, WANG Jianliang, KUANG Jinyuan, TANG Jianping, CHEN Shichao   +4 more
doaj  

Application of fourier transform for early detection of bearing failures in electric motors

Journal Geuthee of Engineering and Energy
This study presents an analysis of bearing fault conditions in electric motors through stator current measurements and their transformation into the frequency domain. Measurements were conducted under two main bearing conditions: normal and damaged, each
Giovanni Dimas Prenata, Muhammad Alif Sofi Syariffudin, Reza Sarwo Widagdo   +2 more
doaj   +1 more source

Occurrence Condition of Electric Current Density in Electrical Pitting

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
Recently, several problems owing to electrical pitting have been observed to be extremely common in small bearings. Many researchers reported on the electrical pitting of bearings used for railcars.
Shoji NOGUCHI, Atsushi KORENAGA, Tohru KANADA   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Processing and fluid flow characteristics of hot isostatically pressed porous alumina for aerostatic bearing applications [PDF]

, 1996
Despite their well known superior load and stiffness characteristics, the wide-spread use of porous aerostatic bearings in preference to other bearing types has been hampered by difficulties in controlling the permeability of the porous material during
Kwan, Y. B. P
core  

Bearing Current Modelling and Investigation in Axial Flux Permanent Magnet Synchronous Motors for Aerospace Applications

, 2022
This paper investigates the bearing current issue of the Axial Flux Permanent Magnet Synchronous Motors (AFPMSM) used in aerospace. The case-study examined in this work is an eVTOL propulsion motor.
Emadi, Ali, Goykhman, Mikhail, Abdalmagid, Mohamed, Callegaro, Alan, Pietrini, Giorgio   +4 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bearing Damage Detection of BLDC Motors Based on Current Envelope Analysis

Measurement Science Review, 2012
This paper proposes current envelope analysis (CEA) to analyze bearing fault signals in brushless direct current (BLDC) motors, and back propagation neural networks (BPNN) to automatically identify bearing faults.
Lee Chun-Yao, Hsieh Yu-Hua
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source