Results 61 to 70 of about 399,584 (308)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An experimental attempt at measurement of bearing load in deep groove ball bearing with eddy current method

open access: yesNihon Kikai Gakkai ronbunshu, 2019
Eddy current method which is uninfluenced by oil film rupture or viscosity change was employed as a simple in-situ estimation method of bearing load acting on deep groove ball bearing operating under low rotational speed.
Akitoshi TAKEUCHI
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Novel Bearing Current Suppression Approach in Doubly-Fed Induction Generators

open access: yesIEEE Access, 2019
Doubly-fed induction generators (DFIGs) are widely used in the wind power generation systems. However, due to the use of the power electronic devices, such as insulated gate bipolar transistor (IGBT), it is inevitable to generate a non-zero common mode ...
Ruifang Liu   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Bearing Ball Property Estimation using Multi-frequency Eddy-current Testing

open access: yes, 2023
The quality of steel balls influences the accuracy, motion performance and service life of the rolling bearing. The eddy-current testing technique plays an important role in the measurement of bearing ball properties, including radius, electrical ...
Liu, Xiaofei   +6 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Condition monitoring of gearboxes using acoustic emission [PDF]

open access: yes, 2010
Acoustic emission (AE) is one of many technologies for health monitoring and diagnosis of rotating machines such as gearboxes. Although significant research has been undertaken in understanding the potential of AE in monitoring gearboxes this has been ...
Eftekharnejad, Babak
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Wind Turbine Generator Reliability: An Exploration of the Root Causes of Generator Bearing Failures [PDF]

open access: yes, 2013
Increasing the availability of multi-megawatt wind turbines (WT) is necessary if the cost of energy generated by wind is to be reduced. Reliability surveys have shown that WT generator bearings have a relatively high failure rate, with failures happening
WHITTLE, MATTHEW
core  

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