Results 51 to 60 of about 184,787 (246)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Mobile- vs. Fixed-Bearing Total Ankle Prostheses
Foot & Ankle Orthopaedics, 2017 Category: Ankle, Ankle Arthritis Introduction/Purpose: Total ankle replacement (TAR) is a well-accepted treatment option in patients with end-stage ankle osteoarthritis.
Alexej Barg MD +2 more
doaj +1 more source
Failure analysis of superconducting bearings
Journal of Physics: Conference Series, 2006 The dynamics of superconductor bearings in a cryogenic failure scenario have been analyzed. As the superconductor warms up, the rotor goes through multiple resonance frequencies, begins to slow down and finally touches down when the superconductor goes through its transition temperature.
Amit Rastogi, A M Campbell, T A Coombs
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Bearing behavior and failure mechanism of squeezed branch piles
Journal of Rock Mechanics and Geotechnical Engineering, 2018 The current practice for the design of squeezed branch piles is mainly based on the calculated bearing capacity of circular piles. Insufficient considerations of the load-transfer mechanism, branch effect and failure mechanism, as well as overreliance on
Minxia Zhang +3 more
doaj +1 more source
Strength predictions of single-lap woven fabric Kenaf composites bolted joints
Journal of Mechanical Engineering and Sciences, 2020 Application of woven fabric kenaf fibers in production of polymeric composites (known as woven fabric kenaf reinforced composite (WKRP)) were readily available in the literatures due to excellent tensile strength and elongation at break.
H. Ahmad, K. Supar
doaj +1 more source
Investigation of Electrical Bearing Failures
, 2023 Cette étude s'intéresse à l'effet des décharges capacitives, induites par les onduleurs d'alimentation des machines électriques, sur les roulements à billes. Un banc d'essai a été construit pour générer artificiellement une rugosité du roulement par électroérosion.
Jammoul, Sara +5 more
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Life Analysis of Wear Fatigue Competition Failure Mechanism of Main Bearing of Boring Machine
Shanghai Jiaotong Daxue xuebaoThe main bearing of a tunneling machine is prone to premature failure under the influence of multiple factors such as wear and fatigue during service, making it difficult to predict its lifetime.
NA Pengyue, WU Zhen, LIU Qi, HUO Junzhou
doaj +1 more source