Results 111 to 120 of about 93,445 (307)

The microstructure of sediment-hosted hydrates: evidence from effective medium modelling of laboratory and borehole seismic data

open access: yes, 2009
Much of our knowledge of hydrate distribution in the subsurface comes frominterpretations of remote seismic measurements. A key step in such interpretations isan effective medium theory that relates the seismic properties of a given sediment toits ...
Minshull, T.A., Chand, S.
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Numerical Modeling and Analysis of Flexure-Pivot Tilting-Pad Bearing

open access: yes, 2017
This paper presents a new approach for modeling flexure-pivot journal bearings (FPJB) employing a three-dimensional (3D) elasto-hydro-dynamic (EHD) lubrication model.
Yeon-Sun Choi, Alan Palazzolo, Junho Suh
core   +1 more source

Research on load distribution optimization of main bearing of shield machine based on nonlinear spring contact force model

open access: yesJixie chuandong
ObjectiveThe main bearing of the shield machine bears complex concentrated loads (including huge axial force and overturning moment). To improve the finite element simulation efficiency of the slewing bearing and reduce its maximum contact load, a non ...
MA Caibing, CHEN Guanci
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

A New Repulsive Type Magnetic Bearing: Modeling and Control

open access: yes
This paper reports on the development of a new repulsive type magnetic bearing system whose radial bearing section makes good utilization of the repulsive forces between stator and rotor permanent magnets resulting a simplified axial control scheme.
山田, 外史   +7 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Towards reliable modeling of challenging f-electrons bearing materials: Experience from modeling of nuclear materials

open access: yes, 2016
Because of steady increase in the availability of computing power, ab initio methods of computational materials science become everyday investigation tools in various research fields.
Kowalski, Piotr   +4 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

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