Results 101 to 110 of about 93,445 (307)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Gas hydrate growth morphologies and their effect on the stiffness and damping of a hydrate bearing sand

, 2008
Using a specially constructed Gas Hydrate Resonant Column (GHRC), the University of Southampton explored different methods of hydrate synthesis and measured the properties of the resulting sediments, such as shear wave velocity (Vs), compressional wave ...
Kingston, Emily, Priest, Jeff, Clayton, Chris R.I., Priest, Jeffery, Clayton, Chris   +4 more
core  

Deterministic Models of an Active Magnetic Bearing System

Journal of Computers, 2007
In this paper the development of mathematical model of voltage-input and current-input active magnetic bearing (AMB) system in deterministic form is presented. The AMB system, which is open-loop unstable and highly coupled due to nonlinearities inherited in the system such as gyroscopic effect and mass imbalance, requires a dynamic controller that can ...
Abdul Rashid Husain, Mohamad Noh Ahmad, Abdul Halim Mohd Yatim   +2 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Permeability prediction in hydrate-bearing sediments via pore network modeling [PDF]

Natural gas hydrates in marine sediments undergo phase transitions under non-equilibrium conditions, making it challenging to accurately measure the permeability characteristics of hydrate-bearing sediments using experimental methods. In this study, pore
Zhang, Yongchao, Luo, Liang, Ma, Jingsheng, Xiao, Ting, Wu, Nengyou, Ma, Jingsheng; id_orcid, Liu, Lele, Ji, Yunkai   +7 more
core   +1 more source

Empirical Model of Bearing Temperature Saturation at Asahan II Hydro-Turbine-Generator

Jurnal Teknik Mesin, 2018
Bearing temperature saturation is a common phenomenon observed during no-load run and full-load tests of Asahan II hydro-turbine-generators. Despite complex heat transfer mechanism involved behind it, simple model can be constructed to predict bearing ...
Bagus Brahmantya Gautama
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A reactive assimilation model for regional-scale cordierite-bearing granitoids: geochemical evidence from the Late Variscan granites of the Central Iberian Zone, Spain [PDF]

, 2008
Regional scale biotite and cordierite-bearing granites (s.l.) in the Variscan of the Central Iberian Zone (CIZ) are spatially closely associated with cordierite-rich nebulites and cordierite-bearing two-mica granites, and with cordierite-rich high grade ...
Ellam, R.M., Ugidos, J. M., Stephens, W. E., Carnicero, A., Stephens, W.E., Ellam, R. M., Ugidos, J.M.   +6 more
core   +1 more source

Thermo-Hydrodynamic Analysis of a Plain Journal Bearing on the Basis of a New Mass Conserving Cavitation Algorithm

Lubricants, 2015
Accurate prediction of cavitation is an important feature in hydrodynamic bearing modeling. Especially for thermo-hydrodynamic modeling, it is crucial to use a mass-conservative cavitation algorithm.
Shivam Alakhramsing, Ron van Ostayen, Rob Eling   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source