Results 81 to 90 of about 93,445 (307)

CONTROL OF A METAPOPULATION HARVESTING MODEL FOR BLACK BEARS

open access: yesNatural Resource Modeling, 2008
Summary: We develop a metapopulation harvesting model that includes density-dependent immigration and emigration and apply Pontryagin's maximum principle to derive an optimal harvesting and reserve design strategy. The model is designed to mimic the black bear population of eastern Tennessee and western North Carolina.
Salinas, René A.   +2 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Effect of Relative Density and Stress Level on the Bearing Capacity of Footings on Sand

open access: yes, 2010
The design of shallow foundations relies on bearing capacity values calculated using empirical procedures that are based in part on solutions obtained using the method of characteristics, which assumes a soil that is perfectly plastic following an ...
Loukidis, D, Salgado, Rodrigo
core  

Dynamic Analysis of Aerostatic Guideway and FEA Model Development [PDF]

open access: yes, 2009
A dynamically optimal design is essential for a motion system to perform high speed operation without compromising its accuracy, settling time and vibration specification.
Lim, Chee Wang
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study on modeling the relationship between bearing load and displacement based on transfer learning

open access: yesZhongguo Jianchuan Yanjiu
Objective This study aims to investigate the dynamic modeling process of the relationship between bearing load and displacement using transfer learning techniques.MethodA multi-supported shafting system was selected as the research object.
Yibin DENG, Peng BAO, Hanhua ZHU
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Thermal modeling of a grease lubricated thrust ball bearing

open access: yes, 2013
International audienceThe aim of this study is to develop a thermal modeling of a grease lubricated rolling bearing in order to analyze the heat evacuated through its solid parts and the lubricant. The system under consideration in this study is a clutch
Changenet, Christophe   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Bearing Dynamics Identification with SINDy-Based Neural Network and Physics Model

open access: yesMachines
Deep neural networks can fit nonlinear bearing vibration responses, but their learned parameters are difficult to relate to contact deformation, rolling element angular position, and other acceleration-generating mechanisms.
Yu Fang   +5 more
doaj   +1 more source

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