Results 31 to 40 of about 5,384,913 (273)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Journal bearing lubrication monitoring based on spectrum cluster analysis of vibration signals [PDF]

, 2015
Journal bearings are critical components for many important machines. Lubrication analysis techniques are often not timely and cost effective for monitoring journal bearings.
Gu, Fengshou, Ball, Andrew, Towsyfyan, Hossein, Wei, Nasha, Hassin, Osama   +4 more
core   +4 more sources

Effect of Engineered Roughness on the Performance of Journal Bearings Lubricated by Bingham Plastic Fluid Using Computational Fluid Dynamics (CFD)

Lubricants, 2022
A journal bearing is a machine element that is used to keep the shaft rotating about its axis. The increasing demand for journal bearing applications in high-speed machines that are efficient and economical has resulted in the need for improvements to ...
Nur Cahyo, P. Paryanto, Ariyana Dwiputra Nugraha, Arionmaro Simaremare, Indra Ardhanayudha Aditya, Bara Songka Laktona Siregar, Mohammad Tauviqirrahman   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Enhancing the Tribological Properties of Bearing Surfaces in Hip Arthroplasty by Shot-Peening the Metal Surface

Lubricants
Total hip arthroplasty (THA) is a surgical procedure for patients with pain and difficulty walking due to hip osteoarthritis. In primary THA, the acetabulum and femoral head are replaced by a prosthesis where the modular femoral head and inner liner of ...
Chavarat Jarungvittayakon, Anak Khantachawana, Paphon Sa-ngasoongsong   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Vibro-Acoustic Characteristic of A Self Aligning Spherical Journal Bearing due to Eccentric Bore Fault [PDF]

Self aligning spherical journal bearing is a type of plain bearings which has spherical surface contact. This type of bearing can accommodate a misalignment problem.
Gu, Fengshou, Ball, Andrew, Raharjo, Parno, Abdusslam, S.A.   +3 more
core   +7 more sources

Theoretical and Experimental Study of Friction Characteristics of Textured Journal Bearing

Micromachines, 2023
The proposed lubrication theory of textured journal bearing is a major innovation in the study of the tribological properties of surface morphology.
Hongtao Wang, Wenbo Bie, Shaolin Zhang, Tengfei Liu   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source