Results 91 to 100 of about 55,867 (251)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Calculation of Shaft Voltage and Bearing Current of Brushless DC Motor Driven by PWM Inverter

, 2005
This paper describes the calculated and measured waveforms of shaft voltage and bearing currents of the brushless DC motor driven by PWM inverter. At first, we discussed the current path of the bearing current when unloaded side bearing is conducting and

core  

Analysis of capacitive discharges in motor bearings under different operation conditions

IET Electric Power Applications
Despite being a well‐known problem, bearing faults are still one of the major challenges that the industry face. The growing use of voltage source inverters imposed the alertness of possible bearing damage due to their high‐frequency signals.
Sara Jammoul, Remus Pusca, Raphael Romary, Guillaume Lefevre, Nicolas Voyer, Guilherme Bueno Mariani   +5 more
doaj   +1 more source

Distributed PV Bearing Capacity Assessment Method Based on Source–Load Coupling Scenarios

Energies
To address the insufficient consideration of system static voltage stability and PV–load coupling in distributed photovoltaic (PV) hosting capacity assessment, this study first investigates the impact of distributed PV integration on power system ...
Yalu Sun, Zhou Wang, Yongcheng Liu, Yi Jiang, Yalong Li   +4 more
doaj   +1 more source

Enhancing Bearing Fault Diagnosis in Induction Motors: A Novel Approach Leveraging Synchronized Deviation of Instantaneous Frequency of Voltage and Current [PDF]

AUT Journal of Electrical Engineering
Current-based methods for bearing fault diagnosis primarily rely on analyzing the current signal, leading to challenges in detecting fault frequencies due to their low magnitude amid the noise in the current spectrum.
Somaye Nazari, Jamal Moshtagh
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Multiphysics-Coupled Load-Bearing Capacity of Piezoelectric Stacks in Low-Temperature Environments

Sensors
Under low-temperature conditions, the load-bearing capacity of piezoelectric stacks arises from coupled thermo-electro-mechanical interactions, with temperature fluctuations, compressive prestress, and excitation voltage critically modulating performance.
Yang Li, Yongping Zheng, Leipeng Song, Zhefan Yao, Hui Zhang, Yonglin Wang, Zhengshun Fei, Xiaozhou Xu, Xinjian Xiang   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source