Results 121 to 130 of about 3,893,066 (230)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Investigation into voltage and process variation-aware manufacturing test

, 2009
Increasing integration and complexity in IC design provides challenges for manufacturing testing. This thesis studies how process and supply voltage variation influence defect behaviour to determine the impact on manufacturing test cost and quality.
Ingelsson, Bo Urban
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

New topology for voltage balancing in railway substations

, 2012
This paper deals with a new technique of voltage unbalance compensation for single phase railway substations. Using the concept of Chopper Controlled Impedance, the authors study the feasibility of an active Steinmetz circuit based on AC choppers.
New topology for voltage balancing in railway substations Raimondo G, Caron H., MARINO, Pompeo, Ladoux P   +3 more
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Experimental Study: Bearing Degradation Caused by Electrical Currents and Voltages at Low Speeds

Lubricants
In electric vehicles (EVs), bearings in traction motors are increasingly prone to electrical damage under operational currents and voltages, leading to accelerated wear and reduced lifespan.
Zi-Fan Li, Ran Cai, Xue-Yuan Nie
semanticscholar   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Influence of Inverter,s Output Voltage du/dt on the Motor and Its Filter Design

Kongzhi Yu Xinxi Jishu, 2012
This paper studies the influence of inverter’s output voltage du/dt on the end voltage and bearing current of the motor, sets up the motor high-frequency model in PSpice and stimulates waveforms of the end voltage.
CHEN Tao, LIU Haitao, WU Bin, JIANG Ping, HUANG Min   +4 more
doaj  

Numerical simulation on transient electromagnetic response of separation layer water in coal seam roof

Scientific Reports
Mining stress induces deformation and fracture of the overlaying rock, which will result in water filling the separation layer if the aquifer finds access to abscission space along the fracture channels.
Haiyan Yang, Junjun Jiao, Qiang Wang, Zhixin Liu, Benyu Su, Yunlei Xu, Wenyu Li, Huageng Ran   +7 more
doaj   +1 more source