Results 41 to 50 of about 1,644,975 (282)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Investigation of the Voltage-Induced Damage Progression on the Raceway Surfaces of Thrust Ball Bearings

Machines, 2022
In the course of the electrification of powertrains, rolling element bearings are increasingly subject to electrical damage. In contrast to mechanically generated pittings, voltage-induced surface damage is a continuous process. Though several approaches
André Harder, Anatoly Zaiat, Florian Michael Becker-Dombrowsky, Steffen Puchtler, Eckhard Kirchner   +4 more
doaj   +1 more source

Voltage security evaluation based on perturbation method [PDF]

, 2009
This is the post-print version of the final paper published in International Journal of Electrical Power & Energy Systems. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing,
Mousavi, A, Rashidinejad, M
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Common-Mode Choke Design to Eliminate Electrostatic Discharge Machining Bearing Currents in Wide-Bandgap Inverter-Fed Motor Drives

Energies
The electrification of mobility sectors, including automotive, aerospace, and robotics, has accelerated the need for compact and high-efficiency power converters in electric motor drives. Wide-bandgap (WBG) semiconductor–based inverters offer significant
Mustafa Memon, Mohamed Diab
doaj   +1 more source

Enhancing Bearing Fault Diagnosis in Induction Motors: A Novel Approach Leveraging Synchronized Deviation of Instantaneous Frequency of Voltage and Current [PDF]

AUT Journal of Electrical Engineering
Current-based methods for bearing fault diagnosis primarily rely on analyzing the current signal, leading to challenges in detecting fault frequencies due to their low magnitude amid the noise in the current spectrum.
Somaye Nazari, Jamal Moshtagh
doaj   +1 more source

Can the Thermodynamic Hodgkin-Huxley Model of Voltage-Dependent Conductance Extrapolate for Temperature? [PDF]

, 2014
Hodgkin and Huxley (H-H) fitted their model of voltage-dependent conductances to experimental data using empirical functions of voltage. The thermodynamic H-H model of voltage dependent conductances is more physically plausible, as it constrains and ...
Michael D. Forrest, Forrest, Michael D., Michael Forrest   +2 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source