Results 231 to 240 of about 250,541 (308)

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng   +10 more
wiley   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

open access: yesAdvanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin   +8 more
wiley   +1 more source

In Situ Reconstructed Crystalline–Amorphous CuNi Nanotubes Unifying Activity and Stability for Oxygen Evolution

open access: yesAdvanced Science, EarlyView.
Controlled electrochemical reconstruction creates a crystalline–amorphous CuNi nanotube that unifies catalytic activity and durability for alkaline oxygen evolution. The conductive metallic core and active amorphous oxide shell work synergistically to deliver low overpotential and exceptional stability exceeding 1000 h, offering a new strategy for ...
Shi‐Yu Zhu   +8 more
wiley   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

open access: yesAdvanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen   +7 more
wiley   +1 more source

Editorial: At the borders of movement, art, and neurosciences, volume II. [PDF]

open access: yesFront Psychol
Cheron G   +4 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy