Results 51 to 60 of about 541,575 (301)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Aspek Flora untuk Penyebutan Standar Kecantikan dalam Bahasa Sunda

Ranah: Jurnal Kajian Bahasa, 2023
The purpose of this research is to reveal the direct meaning or conceptual meaning and figurative meaning or associative meaning. The method used in this research is analytical descriptive method with data collection techniques by literature review ...
Sandi Setiawan, Nunuy Nurjanah, Retty Isnendes, Denny Adrian Nurhuda   +3 more
doaj   +1 more source

B Physics in the Next Millennium

, 1998
As we approach the turn of the century, the Standard Model is still consistent with all our experimental observations and the path to a more complete picture of the fundamental constituents and their interactions has yet to be clearly identified.
Artuso, M.
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Electro-Weak Penguin and Leptonic Decays in BaBar

, 2005
Electro-weak penguin and leptonic decays provide an indirect probe for physics beyond the Standard Model and contribute to the determination of Standard Model parameters.
Abe, Ali, Ali, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Aubert, Bauer, Benson, Bigi, Bigi, Bosch, Bosch, Bosch, Fleischer, Francesca Di Lodovico, Grinstein, Gronau, Gronau, Hewett, Hou, Huang, Hurth, Hurth, Hurth, Kagan, Kagan, Kagan, Krüger, Krüger, Lange, Neubert, Neubert, Neubert, Yang   +41 more
core   +2 more sources

CKM matrix: the `over-consistent' picture of the unitarity triangle [PDF]

, 2000
In presenting an up-to-date account of the experimental knowledge of the CKM matrix, special emphasis is placed on the exceptional degree of consistency shown by the current Standard Model determination of the unitarity triangle; some implications in the
Faccioli, Pietro
core   +5 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Quest for an Ideal Beauty in Toni Morrison's The Bluest Eye

مجلة كلية التربية للبنات, 2019
In The Bluest Eye (1970), the American-African writer, Toni Morrison explores how Western standards of ideal beauty are created and propagated with and among the black community.
Maysoon Taher Muhi, Fatima Ridha
doaj  

Polycarbonate crowns for primary teeth revisited: Restorative options, technique and case reports

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2014
Esthetics by definition is the science of beauty - that particular detail of an animate or inanimate object that makes it appealing to the eye. In the modern, civilized, and cosmetically conscious world, well-contoured and well-aligned white teeth set ...
Karthik Venkataraghavan, John Chan, Sandhya Karthik   +2 more
doaj   +1 more source