Results 71 to 80 of about 544,111 (303)

CKM matrix: the `over-consistent' picture of the unitarity triangle [PDF]

, 2000
In presenting an up-to-date account of the experimental knowledge of the CKM matrix, special emphasis is placed on the exceptional degree of consistency shown by the current Standard Model determination of the unitarity triangle; some implications in the
Faccioli, Pietro
core   +5 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Sources for Chern-Simons theories

, 2008
The coupling between Chern-Simons theories and matter sources defined by branes of different dimensionalities is examined. It is shown that the standard coupling to membranes, such as the one found in supergravity or in string theory, does not operate in
A. Anabalón, A. Anabalón, C. Teitelboim, C. Teitelboim, C.M. Hull, D. Bar-Natan, E. Witten, E. Witten, E. Witten, E. Witten, G.V. Dunne, I.A. Bandos, I.A. Bandos, J. Bagger, J. Zanelli, J.A. Azcárraga de, J.A. Azcárraga de, J.D. Edelstein, J.D. Edelstein, J.F. Schonfeld, M. Bañados, M. Bañados, M. Hassaïne, M. Hassaïne, M. Hatsuda, M. Henneaux, O. Mišković, P. Horava, P. Horava, P. Mora, P. Mora, R. Aros, R. Jackiw, R. Troncoso, U. Gran   +34 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

"Beauty Is the Promise of Happiness"? [PDF]

We measure the impact of individuals' looks on their life satisfaction or happiness. Using five data sets from the U.S., Canada, the U.K., and Germany, we construct beauty measures in different ways that allow putting a lower bound on the true effects of
Abrevaya, Jason, Hamermesh, Daniel S.
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

LHCb Semileptonic Asymmetry

, 2013
A recent LHCb measurement of the CP violating flavour specific asymmetry in $B_s^0$ decays, \asls, is presented. This measurement is based on a data sample corresponding to an integrated luminosity of 1 fb$^{-1}$ of $pp$ collisions at $\sqrt{s}$ $=$ 7 ...
Vesterinen, Mika
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Heavy Flavour Production in pp and Heavy Ion Collisions in QCD Up to LHC Energies

, 2009
Charm production in pp collisions is considered in the framework of perturbative QCD. The values of two parameters, the charm quark mass $m_c$ and the QCD scale mu^2, are determined from the comparison of the theoretical calculations with experimental ...
Merino, C., Pajares, C., Ryzhinskiy, M. M., Shabelski, Yu. M., Shuvaev, A. G.   +4 more
core   +1 more source