Results 111 to 120 of about 24,253,925 (274)
Upregulation of Beclin 1 in the ischemic penumbra [PDF]
Autophagy, 2008 Here we discuss the probable role of autophagy in cerebral ischemia based on our own recent data and the literature. We examined the protein level of Beclin 1 (Bcl-2 interacting protein) and microtubule-associated protein 1 light chain 3 (LC3) which were previously found to promote autophagy.
openaire +2 more sources
Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy [PDF]
, 2015 Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates ...
Aggarwal, Tanya +15 more
core +2 more sources
Disruption of the beclin 1/Bcl-2 autophagy regulatory complex promotes longevity in mice
Nature, 2018 Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established1,2. Here we report lifespan and healthspan extension in a mouse model with increased basal autophagy.
Álvaro F. Fernández +15 more
semanticscholar +1 more source
Cell Death and Disease, 2020 Gastrointestinal stromal tumors (GISTs), the most widespread type of sarcoma, contain driver gene mutations predominantly of receptor tyrosine kinase and platelet-derived growth factor receptor alpha.
Wei Chen +10 more
semanticscholar +1 more source
Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng +6 more
wiley +1 more source
Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules [PDF]
Molecular Cell, 2012 Bim is a proapoptotic BH3-only Bcl-2 family member. In response to death stimuli, Bim dissociates from the dynein light chain 1 (DYNLL1/LC8), where it is inactive, and can then initiate Bax/Bak-mediated mitochondria-dependent apoptosis. We found that Bim depletion increases autophagosome synthesis in cells and in vivo, and this effect is inhibited by ...
Luo, Shouqing +6 more
openaire +3 more sources
Biology, 2020 Simple Summary We described the existence of an integrated Beclin 1, TLR9, and SIRT3 network involving autophagy, oxidative stress, and mitochondria that is essential for empagliflozin to protect against doxorubicin toxicity in the heart.
Chao-Yung Wang +8 more
semanticscholar +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo +8 more
wiley +1 more source
Regulation of autophagy by Beclin 1 in the heart [PDF]
Journal of Molecular and Cellular Cardiology, 2016 Dysregulation of autophagy in cardiomyocytes is implicated in various heart disease conditions. Beclin 1, a mammalian ortholog of yeast Atg6 and a core component of the autophagy machinery, plays a central role in the regulation of autophagy through activation of Vps34.
Yasuhiro, Maejima +2 more
openaire +2 more sources
Autophagy induction regulates influenza virus replication in a time-dependent manner [PDF]
, 2017 Autophagy plays a key role in host defence responses against microbial infections by promoting degradation of pathogens and participating in acquired immunity.
Abdoli, Asghar +12 more
core +1 more source