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Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment [PDF]
Frontiers in ImmunologyThe significant identification of Beclin-1’s function in regulating autophagy flow signified a significant progression in our understanding of cellular operations.
Zhumin Cao +6 more
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Acta Pharmaceutica Sinica B, 2023 Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 kinase) complex, thus controlling autophagy induction and other cellular
Jing Ye +6 more
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Structural insights for selective disruption of Beclin 1 binding to Bcl-2. [PDF]
Commun Biol, 2023 Stimulation of autophagy could provide powerful therapies for multiple diseases, including cancer and neurodegeneration. An attractive drug target for this purpose is Bcl-2, which inhibits autophagy by binding to the Beclin 1 BH3-domain.
Pan YZ +4 more
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Heliyon, 2023 Radioresistance is the major factor of glioblastoma multiforme (GBM) treatment failure and relapse. Hypoxia and autophagy are linked to radioresistance and poor prognosis in solid tumors, but mechanisms remain unknown.
Jielin Wei +8 more
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The elucidation of the dual role of Beclin-1 in ischemic stroke through systems biology modeling [PDF]
iScienceSummary: Beclin-1 plays a pivotal role in the interplay between autophagy and apoptosis in ischemic stroke, influencing both cell survival and death. We developed a mathematical model incorporating the dual role of Beclin-1 to simulate Beclin-1-induced ...
Jun Seok Cha +5 more
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Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65 [PDF]
BiologyAutophagy is a vital cellular pathway in eukaryotic cells, including neurons, where it plays significant roles in neurodevelopment and maintenance. A crucial step in autophagy is the formation of the class III phosphatidylinositol 3-kinase complex 1 ...
Wai Wa Ray Chan +4 more
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Molecules, 2021 Expression levels of the major mammalian autophagy regulator Beclin 1 and its interaction with Bcl-2 regulate the switch between autophagic cell survival and apoptotic cell death pathways.
Miray Turk +5 more
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Beclin-1–Dependent Autophagy Improves Outcomes of Pneumonia-Induced Sepsis
Frontiers in Cellular and Infection Microbiology, 2021 ObjectiveWe previously demonstrated that promoting Beclin-1–dependent autophagy is cardiac protective during endotoxemia shock, suggesting that autophagy-based approaches may become a promising therapeutic strategy for sepsis.
Azadeh Nikouee +4 more
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The Role of Beclin 1-Dependent Autophagy in Cancer
Biology, 2019 Autophagy (self-eating) is an intracellular degradation process used by cells to keep a “clean house”; as it degrades abnormal or damaged proteins and organelles, it helps to fight infections and also provides energy in times of fasting or ...
Silvia Vega-Rubín-de-Celis
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Beclin 1 Phosphorylation – at the Center of Autophagy Regulation
Frontiers in Cell and Developmental Biology, 2018 Autophagy is a tightly regulated catabolic process wherein cells under stress sequester cytosolic constituents like damaged proteins and organelles in double-membrane vesicles called autophagosomes.
Manoj B. Menon +2 more
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