Acta Pharmaceutica Sinica B, 2023 Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 kinase) complex, thus controlling autophagy induction and other cellular
Xian Jiang, Lian Wang, Gu He
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The elucidation of the dual role of Beclin-1 in ischemic stroke through systems biology modeling [PDF]
iScienceSummary: Beclin-1 plays a pivotal role in the interplay between autophagy and apoptosis in ischemic stroke, influencing both cell survival and death. We developed a mathematical model incorporating the dual role of Beclin-1 to simulate Beclin-1-induced ...
Jun Seok Cha +5 more
doaj +2 more sources
Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65 [PDF]
BiologyAutophagy is a vital cellular pathway in eukaryotic cells, including neurons, where it plays significant roles in neurodevelopment and maintenance. A crucial step in autophagy is the formation of the class III phosphatidylinositol 3-kinase complex 1 ...
Wai Wa Ray Chan +4 more
doaj +2 more sources
Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment [PDF]
Frontiers in ImmunologyThe significant identification of Beclin-1’s function in regulating autophagy flow signified a significant progression in our understanding of cellular operations.
Zhumin Cao +6 more
doaj +2 more sources
Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer. [PDF]
PLoS ONE, 2015 Beclin 1 and Beclin 2 are autophagy-related proteins that show similar amino acid sequences and domain structures. Beclin 1 established the first connection between autophagy and cancer. However, the role of Beclin 2 in cancer is unclear.
Jing-Lan Liu +8 more
doaj +1 more source
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. [PDF]
PLoS Genetics, 2014 Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and neurodegenerative diseases, but the molecular mechanism remains elusive. Previous studies showed that Beclin 1 coordinates the assembly of multiple VPS34 complexes whose distinct
Nicole C McKnight +9 more
doaj +1 more source
Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. [PDF]
PLoS ONE, 2012 Beclin 1 is a main actor of autophagy. The expression of Beclin 1 and its prognostic role in gastric cancer is largely unexplored. The purpose of the present study is to investigate the expression of beclin 1 in gastric cancer cells, tissues and its ...
Qi-Rong Geng +6 more
doaj +1 more source
Beclin 1 deficiency correlated with lymph node metastasis, predicts a distinct outcome in intrahepatic and extrahepatic cholangiocarcinoma. [PDF]
PLoS ONE, 2013 Autophagy can be tumor suppressive as well as promotive in regulation of tumorigenesis and disease progression. Accordingly, the prognostic significance of autophagy key regulator Beclin 1 was varied among different tumors.
Tian-Tian Wang +17 more
doaj +1 more source
Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer. [PDF]
PLoS ONE, 2013 Beclin 1, a key regulator of autophagy, has been found to be aberrantly expressed in a variety of human malignancies. Herein, we employed immunohistochemistry (IHC) to detect the protein expression of Beclin 1 in non-small cell lung cancer (NSCLC) and ...
Weihua Zhou +11 more
doaj +1 more source
Molecules, 2021 Expression levels of the major mammalian autophagy regulator Beclin 1 and its interaction with Bcl-2 regulate the switch between autophagic cell survival and apoptotic cell death pathways.
Miray Turk +5 more
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