Results 21 to 30 of about 27,302,953 (278)

Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer. [PDF]

PLoS ONE, 2015
Beclin 1 and Beclin 2 are autophagy-related proteins that show similar amino acid sequences and domain structures. Beclin 1 established the first connection between autophagy and cancer. However, the role of Beclin 2 in cancer is unclear.
Jing-Lan Liu, Fen-Fen Chen, Shun-Fu Chang, Cheng-Nan Chen, Jrhau Lung, Cheng-Hsing Lo, Fang-Hui Lee, Ying-Chou Lu, Chien-Hui Hung   +8 more
doaj   +1 more source

The Role of Bcl-2 and Beclin-1 Complex in “Switching” between Apoptosis and Autophagy in Human Glioma Cells upon LY294002 and Sorafenib Treatment

Cells, 2023
Background: Gliomas are the most malignant tumors of the central nervous system. One of the factors in their high drug resistance is avoiding programmed death (PCD) induction. This is related to the overexpression of intracellular survival pathways: PI3K-
Adrian Zając, Aleksandra Maciejczyk, Joanna Sumorek-Wiadro, Kamil Filipek, K. Deryło, E. Langner, Jarosław Pawelec, Magdalena Wasiak, Mateusz Ścibiorski, Wojciech Rzeski, M. Tchórzewski, Michał Reichert, J. Jakubowicz-Gil   +12 more
semanticscholar   +1 more source

Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. [PDF]

PLoS Genetics, 2014
Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and neurodegenerative diseases, but the molecular mechanism remains elusive. Previous studies showed that Beclin 1 coordinates the assembly of multiple VPS34 complexes whose distinct
Nicole C McKnight, Yun Zhong, Mitchell S Wold, Shiaoching Gong, Greg R Phillips, Zhixun Dou, Yanxiang Zhao, Nathaniel Heintz, Wei-Xing Zong, Zhenyu Yue   +9 more
doaj   +1 more source

Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. [PDF]

PLoS ONE, 2012
Beclin 1 is a main actor of autophagy. The expression of Beclin 1 and its prognostic role in gastric cancer is largely unexplored. The purpose of the present study is to investigate the expression of beclin 1 in gastric cancer cells, tissues and its ...
Qi-Rong Geng, Da-Zhi Xu, Long-Jun He, Jia-Bing Lu, Zhi-Wei Zhou, You-Qing Zhan, Yue Lu   +6 more
doaj   +1 more source

The Beclin 1 interactome [PDF]

Current Opinion in Cell Biology, 2010
The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases.
Congcong, He, Beth, Levine
openaire   +2 more sources

Beclin 1 deficiency correlated with lymph node metastasis, predicts a distinct outcome in intrahepatic and extrahepatic cholangiocarcinoma. [PDF]

PLoS ONE, 2013
Autophagy can be tumor suppressive as well as promotive in regulation of tumorigenesis and disease progression. Accordingly, the prognostic significance of autophagy key regulator Beclin 1 was varied among different tumors.
Tian-Tian Wang, Qing-Hua Cao, Ming-Yuan Chen, Qing Xia, Xin-Juan Fan, Xiao-Kun Ma, Qu Lin, Chang-Chang Jia, Min Dong, Dan-Yun Ruan, Ze-Xiao Lin, Jing-Yun Wen, Li Wei, Xing Li, Zhan-Hong Chen, Lei Wang, Xiang-Yuan Wu, Xiang-Bo Wan   +17 more
doaj   +1 more source

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Beclin 1, an essential autophagy protein, is important for tumor suppression in mice, as well as in human breast and ovarian cancers. However, it is not well understood how Beclin 1 acts as a tumor suppressor.
Tobias Wijshake, Z. Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G Doench, Lynda Bennett, B. Levine   +8 more
semanticscholar   +1 more source

USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity

Nature Communications, 2022
Non-small cell lung cancers (NSCLC) frequently contain KRAS mutation but retain wild-type TP53. Abundant senescent cells are observed in premalignant but not in malignant tumors derived from the Kras-driven mouse model, suggesting that KRAS oncogenic ...
Juan Li, Yang Wang, Y. Luo, Yang Liu, Yong Yi, Jinsong Li, Yang Pan, Weiyuxin Li, Wanbang You, Qingyong Hu, Zhiqiang Zhao, Yujun Zhang, Yang Cao, Lingqiang Zhang, Jun-Bo Yuan, Z. Xiao   +15 more
semanticscholar   +1 more source

METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m6A/IGF2BPs/Beclin-1 Signal Axis

Stem Cells Translational Medicine, 2022
The development of osteoporosis is often accompanied by autophagy disturbance, which also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs).
Mingyu He, Hong Lei, Xiaoqi He, Ying Liu, Ao Wang, Zijing Ren, Xiaoyan Liu, Gege Yan, Wenbo Wang, Yang Wang, Guanghui Li, Tong Wang, Jiaying Pu, Zhihua Shen, Yanquan Wang, Jiajie Xie, Weijie Du, Ye Yuan, Lei Yang   +18 more
semanticscholar   +1 more source

Role for autophagy-related markers Beclin-1 and LC3 in endometriosis

BMC Women's Health, 2022
Background Endometriosis is a common and challenging disease in women of childbearing age with high personal and social costs. Many molecular differences between ectopic and eutopic endometrium present difficulties in the development of new drug ...
Zhiwei Kong, Tingting Yao
semanticscholar   +1 more source