Results 21 to 30 of about 30,020,506 (258)
Loss of Concurrent Regulation of the Expression of BIF-1, BAX, and Beclin-1 in Primary and Metastatic Melanoma. [PDF]
, 2020 Melanoma is one of the most aggressive and drug-resistant cancers. Despite novel promising therapeutic strategies, the prognosis of metastatic melanoma patients remains poor and it is often associated with high relapse rates. Endophilin B1, also known as
Jafari, S M Seyed +3 more
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Neurodegeneration Induces Upregulation of Beclin 1 [PDF]
Autophagy, 2006 Autophagy, a bulk degradation of subcellular constituents, is activated in normal cell growth and development, and represents the major pathway by which the cell maintains a balance between protein synthesis and protein degradation. Autophagy was documented in several neurodegenerative diseases, and under stress conditions the autophagic process can ...
Shlomit, Erlich +2 more
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Involvement of Beclin 1 in Engulfment of Apoptotic Cells [PDF]
Journal of Biological Chemistry, 2012 Efficient apoptotic cell engulfment is important for both tissue homeostasis and immune response in mammals. In the present study, we report that Beclin 1 (a regulator of autophagy) is required for apoptotic cell engulfment. The engulfment process was largely abolished in Beclin 1 knock-out cells, and Beclin 1 knockdown significantly decreased ...
Akimitsu, Konishi +3 more
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Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma. [PDF]
PLoS ONE, 2013 Beclin-1, a key regulator of autophagy. Microtubule-associated protein 1 light chain 3 (LC3), is involved in autophagsome formation during autophagy. The autophagic genes beclin-1 and LC3 paly an important role in the development and progression of tumor.
Juan Wang +5 more
doaj +1 more source
Beclin 1 Complex in Autophagy and Alzheimer Disease [PDF]
Archives of Neurology, 2010 Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be reduced in patients with Alzheimer disease. This review summarizes the current research data that link disturbances in autophagy, a cellular degradation and maintenance pathway, to the development of Alzheimer disease and related neurodegenerative diseases.
Philipp A, Jaeger, Tony, Wyss-Coray
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14-3-3Tau regulates Beclin 1 and is required for autophagy.
PLoS ONE, 2010 BackgroundBeclin 1 plays an essential role in autophagy; however, the regulation of Beclin 1 expression remains largely unexplored. An earlier ChIP-on-chip study suggested Beclin 1 could be an E2F target.
Bing Wang, Shiyun Ling, Weei-Chin Lin
doaj +1 more source
Intestinal epithelial CGAS dampens inflammation by upregulating autophagy
Autophagy Reports, 2022 The pathogenesis of intestinal inflammation involves a complex network of cell signaling pathways. CGAS (cyclic GMP-AMP synthase) is a cytoplasmic DNA sensor that is most known for upregulating interferon-mediated inflammation.
Elizabeth A. Novak +5 more
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Beclin-1 as a neutrophil-specific immune checkpoint [PDF]
Journal of Clinical Investigation, 2019 Neutrophils are early wound healing and inflammation regulators that, due to functional plasticity, can adopt either pro- or antitumor functions. Until recently, beclin-1 was a protein known mainly for its role as a critical regulator of autophagy. In this issue of the JCI, Tan et al.
Yu-Lin Su, Marcin Kortylewski
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A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis. [PDF]
PLoS ONE, 2011 The tumor suppressor activity of Beclin 1 (BECN1), a subunit of class III phosphatidylinositol 3-kinase complex, has been attributed to its regulation of apoptosis and autophagy.
Antonia P Sagona +6 more
doaj +1 more source
Genetic and epigenetic silencing of the
BMC Cancer, 2010 Background Beclin 1, an important autophagy-related protein in human cells, is involved in cell death and cell survival. Beclin 1 mapped to human chromosome 17q21. It is widely expressed in normal mammary epithelial cells.
Wu Yiqing +5 more
doaj +1 more source