Results 11 to 20 of about 30,020,506 (258)
, 2012 Beclin 1/ATG6/Vps30 (UniProtKB/Swiss-Prot Q14457) is a 450 amino-acids length protein, with three domains; BH3 (aminoacid 114 to 123), Coiled Coil domain (CCD; aminoacid 144 to 269) and the Evolutionarily Conserved Domain (ECD; aminoacid 244 to 337). BH3
Molejon, Maria Ines +2 more
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Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration [PDF]
Molecular Neurodegeneration, 2018 Background Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and cell death.
Gregor Bieri +5 more
doaj +3 more sources
ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases [PDF]
Cells, 2019 Autophagy transports cytoplasmic material and organelles to lysosomes for degradation and recycling. Beclin 1 forms a complex with several other autophagy proteins and functions in the initiation phase of autophagy, but the exact role of Beclin 1 ...
Tahira Anwar +7 more
doaj +4 more sources
The Role of Beclin 1-Dependent Autophagy in Cancer [PDF]
Biology, 2019 Autophagy (self-eating) is an intracellular degradation process used by cells to keep a “clean house”; as it degrades abnormal or damaged proteins and organelles, it helps to fight infections and also provides energy in times of fasting or ...
Silvia Vega-Rubín-de-Celis
doaj +4 more sources
Beclin 1 Phosphorylation – at the Center of Autophagy Regulation [PDF]
Frontiers in Cell and Developmental Biology, 2018 Autophagy is a tightly regulated catabolic process wherein cells under stress sequester cytosolic constituents like damaged proteins and organelles in double-membrane vesicles called autophagosomes.
Manoj B. Menon +2 more
doaj +4 more sources
Beclin 1, LC3 and P62 Expression in Equine Sarcoids [PDF]
Animals, 2021 Background: It is well known that δ-bovine papillomaviruses (BPV-1, BPV-2 and BPV-13) are one of the major causative agents of equine sarcoids, the most common equine skin tumors.
Manuela Martano +6 more
doaj +4 more sources
The Beclin 1 interactome [PDF]
Current Opinion in Cell Biology, 2010 The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases.
Congcong, He, Beth, Levine
openaire +2 more sources
Common and divergent functions of Beclin 1 and Beclin 2 [PDF]
Cell Research, 2013 In a recent paper published in Cell, He and colleagues reported the identification and functional characterization of Beclin 2, a mammal-specific homolog of the evolutionarily conserved autophagy-regulatory and oncosuppressive factor Beclin 1. In spite of a non-negligible degree of sequence identity, Beclin 1 and Beclin 2 differ from each other in ...
Lorenzo, Galluzzi, Guido, Kroemer
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Regulation of Beclin 1 in autophagy [PDF]
Autophagy, 2009 Class III phosphatidylinositol 3-kinase (PI3KC3) plays a pleiotropic role in autophagy and protein sorting pathways. The human core complex of PI3KC3 consists of three major components including PI3KC3/hVps34, p150 and Beclin 1. How the specificity of PI3KC3 complex is derived towards autophagy is not clear. Utilizing a sequential affinity purification
Qiming, Sun, Weiliang, Fan, Qing, Zhong
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Beclin-1-Dependent Autophagy Protects the Heart During Sepsis.pdf
, 2023 These results suggest that Beclin-1 protects the heart during sepsis and that the targeted induction of Beclin-1 signaling may have important therapeutic potential.
Beverly Rothermel (16463091)
core +1 more source