Results 11 to 20 of about 27,302,953 (278)

The Beclin 1 network regulates autophagy and apoptosis [PDF]

Cell Death & Differentiation, 2011
Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP(3)R, PINK and survivin) to regulate ...
R. Kang, H. J. Zeh, M. Lotze, D. Tang
semanticscholar   +5 more sources

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration [PDF]

Molecular Neurodegeneration, 2018
Background Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and cell death.
Gregor Bieri, Kurt M. Lucin, Caitlin E. O’Brien, Hui Zhang, Saul A. Villeda, Tony Wyss-Coray   +5 more
doaj   +3 more sources

Polyglutamine tracts regulate beclin 1-dependent autophagy [PDF]

Nature, 2017
Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also varies.
Ashkenazi, A, Bento, CF, Ricketts, T, Vicinanza, M, Siddiqi, F, Pavel, M, Squitieri, F, Hardenberg, MC, Imarisio, S, Menzies, FM, Rubinsztein, DC   +10 more
openaire   +4 more sources

Beclin 1, LC3 and P62 Expression in Equine Sarcoids [PDF]

Animals, 2021
Background: It is well known that δ-bovine papillomaviruses (BPV-1, BPV-2 and BPV-13) are one of the major causative agents of equine sarcoids, the most common equine skin tumors.
Manuela Martano, Gennaro Altamura, Karen Power, Pierluigi Liguori, Brunella Restucci, Giuseppe Borzacchiello, Paola Maiolino   +6 more
doaj   +4 more sources

BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development [PDF]

Cell Death & Differentiation, 2008
Beclin 1/Atg6 is an essential component of the evolutionary conserved PtdIns(3)-kinase (Vps34) protein complex that regulates macroautophagy (autophagy) in eukaryotic cells and also interacts with antiapoptotic Bcl-2 family members, Bcl-2, and Bcl-x(L).
Arsov, I, Li, X, Matthews, G, Coradin, J, Hartmann, B, Simon, A, Sealfon, S, Yue, Z   +7 more
openaire   +5 more sources

Beclin-1 Targeting for Viral Immune Escape [PDF]

Viruses, 2011
Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4+ T cells.
Christian Münz
doaj   +4 more sources

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis [PDF]

Circulation, 2018
Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis have not been clearly defined. Targeted autophagy-based therapeutic approaches for sepsis are not yet developed.
Yuxiao, Sun, Xiao, Yao, Qing-Jun, Zhang, Min, Zhu, Zhi-Ping, Liu, Bo, Ci, Yang, Xie, Deborah, Carlson, Beverly A, Rothermel, Yuxiang, Sun, Beth, Levine, Joseph A, Hill, Steven E, Wolf, Joseph P, Minei, Qun S, Zang   +14 more
openaire   +4 more sources

Disruption of the beclin 1/Bcl-2 autophagy regulatory complex promotes longevity in mice

Nature, 2018
Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established1,2. Here we report lifespan and healthspan extension in a mouse model with increased basal autophagy.
Álvaro F. Fernández, Salwa Sebti, Yongjie Wei, Z. Zou, Mingjun Shi, Kathryn L. McMillan, Congcong He, Tabitha C. Ting, Yang Liu, Wei-Chung Chiang, D. Marciano, G. Schiattarella, G. Bhagat, O. Moe, M. Hu, B. Levine   +15 more
semanticscholar   +3 more sources

Regulation of autophagy by Beclin 1 in the heart [PDF]

Journal of Molecular and Cellular Cardiology, 2016
Dysregulation of autophagy in cardiomyocytes is implicated in various heart disease conditions. Beclin 1, a mammalian ortholog of yeast Atg6 and a core component of the autophagy machinery, plays a central role in the regulation of autophagy through activation of Vps34.
Yasuhiro, Maejima, Mitsuaki, Isobe, Junichi, Sadoshima   +2 more
openaire   +4 more sources

Stress reduction through cortical bone thickening improves bone mechanical behavior in adult female Beclin-1+/− mice [PDF]

Frontiers in Bioengineering and Biotechnology
Fragility fractures, which are more prevalent in women, may be significantly influenced by autophagy due to altered bone turnover. As an essential mediator of autophagy, Beclin-1 modulates bone homeostasis by regulating osteoclast and chondrocyte ...
Jiaojiao Yang, Jiaojiao Yang, Qilin Pei, Qilin Pei, Xingfan Wu, Xin Dai, Xi Li, Jun Pan, Bin Wang   +8 more
doaj   +2 more sources