Results 11 to 20 of about 31,119 (206)
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration [PDF]
Molecular Neurodegeneration, 2018 Background Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and cell death.
Gregor Bieri +5 more
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The Role of Beclin 1-Dependent Autophagy in Cancer [PDF]
Biology, 2019 Autophagy (self-eating) is an intracellular degradation process used by cells to keep a “clean house”; as it degrades abnormal or damaged proteins and organelles, it helps to fight infections and also provides energy in times of fasting or ...
Silvia Vega-Rubín-de-Celis
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Beclin 1 Phosphorylation – at the Center of Autophagy Regulation [PDF]
Frontiers in Cell and Developmental Biology, 2018 Autophagy is a tightly regulated catabolic process wherein cells under stress sequester cytosolic constituents like damaged proteins and organelles in double-membrane vesicles called autophagosomes.
Manoj B. Menon +2 more
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Beclin 1, LC3 and P62 Expression in Equine Sarcoids [PDF]
Animals, 2021 Background: It is well known that δ-bovine papillomaviruses (BPV-1, BPV-2 and BPV-13) are one of the major causative agents of equine sarcoids, the most common equine skin tumors.
Manuela Martano +6 more
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Beclin-1 Targeting for Viral Immune Escape [PDF]
Viruses, 2011 Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4+ T cells.
Christian Münz
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The Beclin 1 interactome [PDF]
Current Opinion in Cell Biology, 2010 The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases.
Congcong, He, Beth, Levine
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Common and divergent functions of Beclin 1 and Beclin 2 [PDF]
Cell Research, 2013 In a recent paper published in Cell, He and colleagues reported the identification and functional characterization of Beclin 2, a mammal-specific homolog of the evolutionarily conserved autophagy-regulatory and oncosuppressive factor Beclin 1. In spite of a non-negligible degree of sequence identity, Beclin 1 and Beclin 2 differ from each other in ...
Lorenzo, Galluzzi, Guido, Kroemer
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Regulation of Beclin 1 in autophagy [PDF]
Autophagy, 2009 Class III phosphatidylinositol 3-kinase (PI3KC3) plays a pleiotropic role in autophagy and protein sorting pathways. The human core complex of PI3KC3 consists of three major components including PI3KC3/hVps34, p150 and Beclin 1. How the specificity of PI3KC3 complex is derived towards autophagy is not clear. Utilizing a sequential affinity purification
Qiming, Sun, Weiliang, Fan, Qing, Zhong
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Neurodegeneration Induces Upregulation of Beclin 1 [PDF]
Autophagy, 2006 Autophagy, a bulk degradation of subcellular constituents, is activated in normal cell growth and development, and represents the major pathway by which the cell maintains a balance between protein synthesis and protein degradation. Autophagy was documented in several neurodegenerative diseases, and under stress conditions the autophagic process can ...
Shlomit, Erlich +2 more
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Molecules, 2021 Expression levels of the major mammalian autophagy regulator Beclin 1 and its interaction with Bcl-2 regulate the switch between autophagic cell survival and apoptotic cell death pathways.
Miray Turk +5 more
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