The elucidation of the dual role of Beclin-1 in ischemic stroke through systems biology modeling [PDF]
iScienceSummary: Beclin-1 plays a pivotal role in the interplay between autophagy and apoptosis in ischemic stroke, influencing both cell survival and death. We developed a mathematical model incorporating the dual role of Beclin-1 to simulate Beclin-1-induced ...
Jun Seok Cha +5 more
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Acta Pharmaceutica Sinica B, 2023 Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 kinase) complex, thus controlling autophagy induction and other cellular
Yanghui Zhu, Lian Wang, Xian Jiang
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Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65 [PDF]
BiologyAutophagy is a vital cellular pathway in eukaryotic cells, including neurons, where it plays significant roles in neurodevelopment and maintenance. A crucial step in autophagy is the formation of the class III phosphatidylinositol 3-kinase complex 1 ...
Wai Wa Ray Chan +4 more
doaj +2 more sources
Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment [PDF]
Frontiers in ImmunologyThe significant identification of Beclin-1’s function in regulating autophagy flow signified a significant progression in our understanding of cellular operations.
Zhumin Cao +6 more
doaj +2 more sources
Electroacupuncture Ameliorates Premature Ovarian Insufficiency by Inhibiting METTL3-Mediated m6A Methylation of Beclin 1 mRNA in Granulosa Cells. [PDF]
Food Sci NutrA high‐fat, high‐sugar (HFHS) diet induces premature ovarian insufficiency (POI), characterized by reduced follicular reserve, increased atresia, fibrosis, and excessive granulosa cell autophagy. Electroacupuncture (EA) at CV4, ST36, and SP6 suppresses METTL3 expression and reduces m6A methylation of Beclin1 mRNA, thereby limiting Beclin1 translation ...
Ling L +9 more
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Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer. [PDF]
PLoS ONE, 2015 Beclin 1 and Beclin 2 are autophagy-related proteins that show similar amino acid sequences and domain structures. Beclin 1 established the first connection between autophagy and cancer. However, the role of Beclin 2 in cancer is unclear.
Jing-Lan Liu +8 more
doaj +1 more source
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. [PDF]
PLoS Genetics, 2014 Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and neurodegenerative diseases, but the molecular mechanism remains elusive. Previous studies showed that Beclin 1 coordinates the assembly of multiple VPS34 complexes whose distinct
Nicole C McKnight +9 more
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Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. [PDF]
PLoS ONE, 2012 Beclin 1 is a main actor of autophagy. The expression of Beclin 1 and its prognostic role in gastric cancer is largely unexplored. The purpose of the present study is to investigate the expression of beclin 1 in gastric cancer cells, tissues and its ...
Qi-Rong Geng +6 more
doaj +1 more source
Beclin 1 deficiency correlated with lymph node metastasis, predicts a distinct outcome in intrahepatic and extrahepatic cholangiocarcinoma. [PDF]
PLoS ONE, 2013 Autophagy can be tumor suppressive as well as promotive in regulation of tumorigenesis and disease progression. Accordingly, the prognostic significance of autophagy key regulator Beclin 1 was varied among different tumors.
Tian-Tian Wang +17 more
doaj +1 more source
Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer. [PDF]
PLoS ONE, 2013 Beclin 1, a key regulator of autophagy, has been found to be aberrantly expressed in a variety of human malignancies. Herein, we employed immunohistochemistry (IHC) to detect the protein expression of Beclin 1 in non-small cell lung cancer (NSCLC) and ...
Weihua Zhou +11 more
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