Results 31 to 40 of about 32,253 (206)
Upregulation of Beclin 1 in the ischemic penumbra [PDF]
Autophagy, 2008 Here we discuss the probable role of autophagy in cerebral ischemia based on our own recent data and the literature. We examined the protein level of Beclin 1 (Bcl-2 interacting protein) and microtubule-associated protein 1 light chain 3 (LC3) which were previously found to promote autophagy.
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Expression of beclin-1 in the microenvironment of invasive ductal carcinoma of the breast: correlation with prognosis and the cancer-stromal interaction. [PDF]
PLoS ONE, 2015 We examined the pathobiological properties of beclin-1, which is a key regulator of autophagosome formation in invasive ductal carcinoma of the breast, with a particular focus on the cancer microenvironment.
Akemi Morikawa +6 more
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Expression of Beclin 1 in Bladder Cancer and Its Clinical Significance
The International Journal of Biological Markers, 2013 Background The aim of this study is to explore the expression of beclin 1, an autophagy gene, in bladder cancer and to evaluate its clinical and prognostic significance in patients with bladder cancer. Methods Beclin 1 expression was examined at mRNA and
Gui-hong Liu +7 more
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Cellular Physiology and Biochemistry, 2017 Background/Aims: Although small cell lung cancer (SCLC) is sensitive to initial chemotherapy, patients experience tumor recurrence and metastasis, leading to treatment failure.
Xiang Yang +4 more
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Targeting Beclin 1 for viral subversion of macroautophagy [PDF]
Autophagy, 2010 We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell.
Gannagé Monique +2 more
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Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia
Haematologica, 2020 Autophagy is a genetically regulated process of adaptation to metabolic stress and was recently shown to be involved in the treatment response of chronic myeloid leukemia (CML).
Chuanjiang Yu +14 more
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The Expression of The Autophagy Gene Beclin-1 mRNA and Protein in Ectopic and Eutopic Endometrium of Patients with Endometriosis [PDF]
International Journal of Fertility and Sterility, 2015 Background To investigate the expression of Beclin-1 mRNA and protein in eutopic and ectopic endometrium of women with and without endometriosis, and evaluate the association of Beclin-1 protein expression and serum CA125 levels in the endometriosis ...
Longyu Zhang +4 more
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eLife, 2015 Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are ...
Yongjie Wei +8 more
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Ecotoxicology and Environmental Safety, 2022 Arsenite is a toxic metalloid that causes various adverse effects in brain. However, the underlying mechanisms of arsenite-induced neurotoxicity remain poorly understood.
Hongmei Zhou +10 more
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Autophagy, Beclin 1, and Their Relation To Oncogenesis [PDF]
Laboratory Medicine, 2008 Autophagy is a lysosomal degradation pathway for cytoplasmic material. Recent studies have demonstrated that autophagy is related closely to the occurrence and development of tumor. Beclin 1 was the first identified mammalian gene with a role in mediating autophagy.
Yang Sun, Zhi-Lan Peng
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