Results 31 to 40 of about 45,804 (237)
Beclin 1 Complex in Autophagy and Alzheimer Disease [PDF]
Archives of Neurology, 2010 Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be reduced in patients with Alzheimer disease. This review summarizes the current research data that link disturbances in autophagy, a cellular degradation and maintenance pathway, to the development of Alzheimer disease and related neurodegenerative diseases.
Philipp A, Jaeger, Tony, Wyss-Coray
openaire +2 more sources
Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma. [PDF]
PLoS ONE, 2013 It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear.In the present
Huan-Xin Lin +9 more
doaj +1 more source
Connexins : substrates and regulators of autophagy [PDF]
, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +1 more source
Genetic and epigenetic silencing of the
BMC Cancer, 2010 Background Beclin 1, an important autophagy-related protein in human cells, is involved in cell death and cell survival. Beclin 1 mapped to human chromosome 17q21. It is widely expressed in normal mammary epithelial cells.
Wu Yiqing +5 more
doaj +1 more source
Beclin-1 as a neutrophil-specific immune checkpoint [PDF]
Journal of Clinical Investigation, 2019 Neutrophils are early wound healing and inflammation regulators that, due to functional plasticity, can adopt either pro- or antitumor functions. Until recently, beclin-1 was a protein known mainly for its role as a critical regulator of autophagy. In this issue of the JCI, Tan et al.
Yu-Lin Su, Marcin Kortylewski
openaire +2 more sources
Heliyon, 2023 Radioresistance is the major factor of glioblastoma multiforme (GBM) treatment failure and relapse. Hypoxia and autophagy are linked to radioresistance and poor prognosis in solid tumors, but mechanisms remain unknown.
Jielin Wei +8 more
doaj +1 more source
TRIM50 regulates Beclin 1 proautophagic activity
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2018 Autophagy is a catabolic process needed for maintaining cell viability and homeostasis in response to numerous stress conditions. Emerging evidence indicates that the ubiquitin system has a major role in this process. TRIMs, an E3 ligase protein family, contribute to selective autophagy acting as receptors and regulators of the autophagy proteins ...
Fusco C +13 more
openaire +3 more sources
The VMP1-Beclin 1 interaction regulates autophagy induction [PDF]
Scientific Reports, 2013 The Vacuole Membrane Protein 1 -VMP1- is a pancreatitis-associated transmembrane protein whose expression triggers autophagy in several human diseases. In the current study, we unveil the mechanism through which this protein induces autophagosome formation in mammalian cells.
Molejon, Maria Ines +4 more
openaire +3 more sources
The Role of Beclin 1-Dependent Autophagy in Cancer
Biology, 2019 Autophagy (self-eating) is an intracellular degradation process used by cells to keep a “clean house”; as it degrades abnormal or damaged proteins and organelles, it helps to fight infections and also provides energy in times of fasting or ...
Silvia Vega-Rubín-de-Celis
doaj +1 more source
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. [PDF]
, 2018 SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as a potential therapeutic target in a variety of neurodegenerative diseases, including Parkinson's disease (PD ...
Deng, Yong-Ning +6 more
core +1 more source