Results 11 to 20 of about 31,069 (166)
Molecules, 2021 Expression levels of the major mammalian autophagy regulator Beclin 1 and its interaction with Bcl-2 regulate the switch between autophagic cell survival and apoptotic cell death pathways.
Miray Turk +5 more
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Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
Molecular Neurodegeneration, 2018 Background Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and cell death.
Gregor Bieri +5 more
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ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases
Cells, 2019 Autophagy transports cytoplasmic material and organelles to lysosomes for degradation and recycling. Beclin 1 forms a complex with several other autophagy proteins and functions in the initiation phase of autophagy, but the exact role of Beclin 1 ...
Tahira Anwar +7 more
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Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma. [PDF]
PLoS ONE, 2013 Beclin-1, a key regulator of autophagy. Microtubule-associated protein 1 light chain 3 (LC3), is involved in autophagsome formation during autophagy. The autophagic genes beclin-1 and LC3 paly an important role in the development and progression of tumor.
Juan Wang +5 more
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14-3-3Tau regulates Beclin 1 and is required for autophagy.
PLoS ONE, 2010 BackgroundBeclin 1 plays an essential role in autophagy; however, the regulation of Beclin 1 expression remains largely unexplored. An earlier ChIP-on-chip study suggested Beclin 1 could be an E2F target.
Bing Wang, Shiyun Ling, Weei-Chin Lin
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A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis. [PDF]
PLoS ONE, 2011 The tumor suppressor activity of Beclin 1 (BECN1), a subunit of class III phosphatidylinositol 3-kinase complex, has been attributed to its regulation of apoptosis and autophagy.
Antonia P Sagona +6 more
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Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma. [PDF]
PLoS ONE, 2013 It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear.In the present
Huan-Xin Lin +9 more
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Genetic and epigenetic silencing of the
BMC Cancer, 2010 Background Beclin 1, an important autophagy-related protein in human cells, is involved in cell death and cell survival. Beclin 1 mapped to human chromosome 17q21. It is widely expressed in normal mammary epithelial cells.
Wu Yiqing +5 more
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Heliyon, 2023 Radioresistance is the major factor of glioblastoma multiforme (GBM) treatment failure and relapse. Hypoxia and autophagy are linked to radioresistance and poor prognosis in solid tumors, but mechanisms remain unknown.
Jielin Wei +8 more
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Beclin 1, LC3 and P62 Expression in Equine Sarcoids
Animals, 2021 Background: It is well known that δ-bovine papillomaviruses (BPV-1, BPV-2 and BPV-13) are one of the major causative agents of equine sarcoids, the most common equine skin tumors.
Manuela Martano +6 more
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