Results 41 to 50 of about 32,253 (206)

Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG. [PDF]

PLoS ONE, 2017
Anti-apoptotic Bcl-2 and Bcl-xL are proposed to regulate starvation-induced autophagy by directly interacting with Beclin 1. Beclin 1 is also thought to be involved in multiple vesicle trafficking pathways such as endocytosis by binding to Atg14L and ...
Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa   +5 more
doaj   +1 more source

Autophagy plays a protective role against Trypanosoma cruzi infection in mice

Virulence, 2019
Autophagy is a catabolic pathway required for cellular and organism homeostasis. Autophagy participates in the innate and adaptive immune responses at different levels.
Ana Florencia Casassa, María Cristina Vanrell, María Isabel Colombo, Roberta A. Gottlieb, Patricia Silvia Romano   +4 more
doaj   +1 more source

Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells. [PDF]

PLoS ONE, 2014
Beclin 1 interacts with UV-irradiation-resistance-associated gene (UVRAG) to form core complexes that induce autophagy. While cells with defective autophagy are prone to genomic instability that contributes to tumorigenesis, it is unknown whether Beclin1
Jae Myung Park, David Tougeron, Shengbing Huang, Koichi Okamoto, Frank A Sinicrope   +4 more
doaj   +1 more source

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

Neurobiology of Disease, 2008
Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic contents which seems to be implicated in a variety of physiological and pathological conditions relevant to neurological diseases.
A. Rami, A. Langhagen, S. Steiger
doaj   +1 more source

Prognostic value of Beclin 1, EGFR and ALK in non-squamous non-small cell lung cancer

Discover Oncology, 2022
Non-small cell lung cancer (NSCLC) is one of the most malignant tumors. The study was carried out to investigate the prognostic value of Beclin 1, EGFR and ALK for this cancer.
Yanhui Wan, Youhui Qian, Youyu Wang, Fuyuan Fang, Guodong Wu   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

ULK1 targets Beclin-1 in autophagy [PDF]

Nature Cell Biology, 2013
The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream ...
Volodymyr Y. Nazarko, Qing Zhong
openaire   +1 more source

Beclin-1 increases with obstructive sleep apnea severity

Sleep Medicine, 2021
Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults ...
Schlemmer, Frédéric, Zysman, Maéva, Ribeiro Baptista, Bruno, Audureau, Etienne, Covali Noroc, Ala, Ridoux, Audrey, Derumeaux, Geneviève, Adnot, Serge, Maitre, Bernard, Le Corvoisier, Philippe, Lanone, Sophie, Boczkowski, Jorge, Boyer, Laurent   +12 more
openaire   +2 more sources

Downregulation of microRNA-30a-5p contributes to the replication of duck enteritis virus by regulating Beclin-1-mediated autophagy

Virology Journal, 2019
Background MicroRNAs (miRNAs) is increasingly recognized as an important element in regulating virus-host interactions. Our previous results showed that cellular miR-30a-5p was significantly downregulated after duck enteritis virus (DEV) infection cell ...
Xianglong Wu, Renyong Jia, Mingshu Wang, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Qiao Yang, Ying Wu, Zhongqiong Yin, Shaqiu Zhang, Juan Huang, Ling Zhang, Yunya Liu, Yanling Yu, Leichang Pan, Bin Tian, Mujeeb Ur Rehman, Xiaoyue Chen, Anchun Cheng   +19 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source