Results 41 to 50 of about 31,119 (206)

Autophagy, Beclin 1, and Their Relation To Oncogenesis [PDF]

Laboratory Medicine, 2008
Autophagy is a lysosomal degradation pathway for cytoplasmic material. Recent studies have demonstrated that autophagy is related closely to the occurrence and development of tumor. Beclin 1 was the first identified mammalian gene with a role in mediating autophagy.
Yang Sun, Zhi-Lan Peng
openaire   +1 more source

The Expression of The Autophagy Gene Beclin-1 mRNA and Protein in Ectopic and Eutopic Endometrium of Patients with Endometriosis [PDF]

International Journal of Fertility and Sterility, 2015
Background To investigate the expression of Beclin-1 mRNA and protein in eutopic and ectopic endometrium of women with and without endometriosis, and evaluate the association of Beclin-1 protein expression and serum CA125 levels in the endometriosis ...
Longyu Zhang, Ying Liu, Yuping Xu, Huan Wu, Zhaolian Wei   +4 more
doaj   +1 more source

Downregulation of beclin 1 restores arsenite-induced impaired autophagic flux by improving the lysosomal function in cortex

Ecotoxicology and Environmental Safety, 2022
Arsenite is a toxic metalloid that causes various adverse effects in brain. However, the underlying mechanisms of arsenite-induced neurotoxicity remain poorly understood.
Hongmei Zhou, Hong Ling, Yunlong Li, Xuejun Jiang, Shuqun Cheng, Golamaully Mohammad Zubeir, Yinyin Xia, Xia Qin, Jun Zhang, Zhen Zou, Chengzhi Chen   +10 more
doaj   +1 more source

Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia

Haematologica, 2020
Autophagy is a genetically regulated process of adaptation to metabolic stress and was recently shown to be involved in the treatment response of chronic myeloid leukemia (CML).
Chuanjiang Yu, Sivahari P. Gorantla, Alina Müller-Rudorf, Tony A. Müller, Stefanie Kreutmair, Corinna Albers, Lena Jakob, Lena J. Lippert, Zhenyu Yue, Monika Engelhardt, Marie Follo, Robert Zeiser, Tobias B. Huber, Justus Duyster, Anna L. Illert   +14 more
doaj   +1 more source

Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG. [PDF]

PLoS ONE, 2017
Anti-apoptotic Bcl-2 and Bcl-xL are proposed to regulate starvation-induced autophagy by directly interacting with Beclin 1. Beclin 1 is also thought to be involved in multiple vesicle trafficking pathways such as endocytosis by binding to Atg14L and ...
Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa   +5 more
doaj   +1 more source

ULK1 targets Beclin-1 in autophagy [PDF]

Nature Cell Biology, 2013
The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream ...
Volodymyr Y. Nazarko, Qing Zhong
openaire   +1 more source

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

Neurobiology of Disease, 2008
Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic contents which seems to be implicated in a variety of physiological and pathological conditions relevant to neurological diseases.
A. Rami, A. Langhagen, S. Steiger
doaj   +1 more source

Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells. [PDF]

PLoS ONE, 2014
Beclin 1 interacts with UV-irradiation-resistance-associated gene (UVRAG) to form core complexes that induce autophagy. While cells with defective autophagy are prone to genomic instability that contributes to tumorigenesis, it is unknown whether Beclin1
Jae Myung Park, David Tougeron, Shengbing Huang, Koichi Okamoto, Frank A Sinicrope   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Beclin-1 increases with obstructive sleep apnea severity

Sleep Medicine, 2021
Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults ...
Schlemmer, Frédéric, Zysman, Maéva, Ribeiro Baptista, Bruno, Audureau, Etienne, Covali Noroc, Ala, Ridoux, Audrey, Derumeaux, Geneviève, Adnot, Serge, Maitre, Bernard, Le Corvoisier, Philippe, Lanone, Sophie, Boczkowski, Jorge, Boyer, Laurent   +12 more
openaire   +2 more sources