Results 41 to 50 of about 27,302,953 (278)
Oncogene, 2021 Cancer stem cells (CSCs) are characterized by robust self-renewal and tumorigenesis and are responsible for metastasis, drug resistance, and angiogenesis. However, the molecular mechanisms for the regulation of CSC homeostasis are incompletely understood.
Qingli Bie +10 more
semanticscholar +1 more source
Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells [PDF]
, 2018 Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits.
Flores, M. Luz +7 more
core +1 more source
ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases
Cells, 2019 Autophagy transports cytoplasmic material and organelles to lysosomes for degradation and recycling. Beclin 1 forms a complex with several other autophagy proteins and functions in the initiation phase of autophagy, but the exact role of Beclin 1 ...
Tahira Anwar +7 more
doaj +1 more source
Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma. [PDF]
PLoS ONE, 2013 Beclin-1, a key regulator of autophagy. Microtubule-associated protein 1 light chain 3 (LC3), is involved in autophagsome formation during autophagy. The autophagic genes beclin-1 and LC3 paly an important role in the development and progression of tumor.
Juan Wang +5 more
doaj +1 more source
Kidney International, 2021 Autophagy regulator beclin 1 activity determines the severity of kidney damage induced by ischemia reperfusion injury, but its role in kidney recovery and fibrosis are unknown and its therapeutic potentials have not been tested.
Mingjun Shi +6 more
semanticscholar +1 more source
ULK1 targets Beclin-1 in autophagy [PDF]
Nature Cell Biology, 2013 The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream ...
Volodymyr Y. Nazarko, Qing Zhong
openaire +1 more source
14-3-3Tau regulates Beclin 1 and is required for autophagy.
PLoS ONE, 2010 BackgroundBeclin 1 plays an essential role in autophagy; however, the regulation of Beclin 1 expression remains largely unexplored. An earlier ChIP-on-chip study suggested Beclin 1 could be an E2F target.
Bing Wang, Shiyun Ling, Weei-Chin Lin
doaj +1 more source
A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis. [PDF]
PLoS ONE, 2011 The tumor suppressor activity of Beclin 1 (BECN1), a subunit of class III phosphatidylinositol 3-kinase complex, has been attributed to its regulation of apoptosis and autophagy.
Antonia P Sagona +6 more
doaj +1 more source
Quantitative assessment of cell fate decision between autophagy and apoptosis [PDF]
, 2017 Autophagy and apoptosis are cellular processes that regulate cell survival and death, the former by eliminating dysfunctional components in the cell, the latter by programmed cell death.
Bahar, Ivet +6 more
core +3 more sources
Beclin-1 increases with obstructive sleep apnea severity
Sleep Medicine, 2021 Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults ...
Schlemmer, Frédéric +12 more
openaire +2 more sources