Results 41 to 50 of about 30,020,506 (258)
Expression of Beclin 1 in Bladder Cancer and Its Clinical Significance
The International Journal of Biological Markers, 2013 Background The aim of this study is to explore the expression of beclin 1, an autophagy gene, in bladder cancer and to evaluate its clinical and prognostic significance in patients with bladder cancer. Methods Beclin 1 expression was examined at mRNA and
Gui-hong Liu +7 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2017 Background/Aims: Although small cell lung cancer (SCLC) is sensitive to initial chemotherapy, patients experience tumor recurrence and metastasis, leading to treatment failure.
Xiang Yang +4 more
doaj +1 more source
Targeting Beclin 1 for viral subversion of macroautophagy [PDF]
Autophagy, 2010 We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell.
Gannagé Monique +2 more
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Inflachromene inhibits autophagy through modulation of Beclin 1 activity [PDF]
, 2018 Autophagy is a central intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles, and regulation of autophagy is essential for homeostasis.
신전수, 곽만섭
core +3 more sources
eLife, 2015 Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are ...
Yongjie Wei +8 more
doaj +1 more source
Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia
Haematologica, 2020 Autophagy is a genetically regulated process of adaptation to metabolic stress and was recently shown to be involved in the treatment response of chronic myeloid leukemia (CML).
Chuanjiang Yu +14 more
doaj +1 more source
The Expression of The Autophagy Gene Beclin-1 mRNA and Protein in Ectopic and Eutopic Endometrium of Patients with Endometriosis [PDF]
International Journal of Fertility and Sterility, 2015 Background To investigate the expression of Beclin-1 mRNA and protein in eutopic and ectopic endometrium of women with and without endometriosis, and evaluate the association of Beclin-1 protein expression and serum CA125 levels in the endometriosis ...
Longyu Zhang +4 more
doaj +1 more source
Investigating the role of Beclin-1 in Schwann cell maturation and development in vivo
, 2023 reservedL'autofagia è un processo cellulare coinvolto nel mantenimento dell'omeostasi e nel garantire la sopravvivenza della cellula in diverse condizioni non fisiologiche come il digiuno o le infezioni.
D'AMORE, RACHELE
core
Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner [PDF]
, 2014 Mcl-1 is a unique Bcl-2 family member that plays crucial roles in apoptosis. Apoptosis-unrelated functions of Mcl-1 are however emerging, further justifying its tight regulation. Here we unravel a novel mechanism of Mcl-1 regulation mediated by the haplo-
M. Elgendy +19 more
core +1 more source
Beclin-1 Targeting for Viral Immune Escape [PDF]
Viruses, 2011 Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4+ T cells. Due to these protective functions during immune responses, several pathogens, including RNA and DNA viruses, have developed strategies to inhibit ...
openaire +5 more sources