Results 61 to 70 of about 30,020,506 (258)
Biochemical and Genetic Studies of Beclin 1 Function in Autophagy [PDF]
, 2009 Beclin 1 is a mammalian autophagy protein and has important functions in development, tumor suppression and neurodegeneration. Beclin 1 exists in a protein complex with Vps34, which is a class III phosphatidylinositol (PtdIns) 3-kinase and mediates ...
Zhong, Yun
core +1 more source
The Role Beclin 1 on Autophagy in Polycystic Ovary Syndrome [PDF]
, 2023 This research was made to evaluate the plasma beclin-1 level in the pathogenesis of polycystic ovary syndrome in females and to find relationship between autophagy and polycystic ovary syndrome through determination of the biochemical parameters and ...
Abdullah, Assalah Abd-A lhussein +2 more
core +1 more source
ULK1 targets Beclin-1 in autophagy [PDF]
Nature Cell Biology, 2013 The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream ...
Volodymyr Y. Nazarko, Qing Zhong
openaire +1 more source
Beclin-1 increases with obstructive sleep apnea severity
Sleep Medicine, 2021 Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults ...
Schlemmer, Frédéric +12 more
openaire +2 more sources
Journal of the Egyptian Women’s Dermatologic Society, 2021 Background Autophagy is a lysosomal degradative process that is essential for the cell viability, homeostasis, and maintenance. Objective To measure microtubule-associated protein 1 light chain 3 (LC3)-I, LC3-II, and beclin 1 as indicators of autophagy ...
Ghada M El-Hanafy +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Short-term fenofibrate treatment improves ultrastructure of hepatocytes of old rats
Folia Histochemica et Cytobiologica, 2021 INTRODUCTION: Fenofibrate (FN) is a hypolipemic drug used for the treatment of mixed dyslipidemia. Since in our previous study FN administration to young and old rats adversely affected the serum activity of liver marker enzymes, we decided to examine ...
Adrian Zubrzycki +3 more
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Beclin 1+/− does not accelerate lymphoma formation.
, 2013 A) Primary thymocytes were isolated from mice of the indicated genotypes. Immunoblots for Beclin 1, and actin as a loading control are shown. The ratio of Beclin 1 to actin for each mouse is shown below the immunoblots. Kaplan-Meier analysis for lymphoma
Sih-han Wang (351494) +3 more
core +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source