Results 71 to 80 of about 30,020,506 (258)

Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases

, 2020
Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications.
Lisa Kinch, Silvia Vega-Rubín-de-Celis, Samuel Peña-Llopis   +2 more
core   +1 more source

Beclin-1 is required for chromosome congression and proper outer kinetochore assembly. [PDF]

, 2013
International audienceThe functions of Beclin-1 in macroautophagy, tumorigenesis and cytokinesis are thought to be mediated by its association with the PI3K-III complex.
Katy Janvier, Frémont, Stéphane, Galloux, Marie, Karess, Roger E, Marie Galloux, Gérard, Annabelle, Annabelle Gérard, Stéphane Frémont, Roger E Karess, Clarisse Berlioz‐Torrent, Janvier, Katy, Berlioz-Torrent, Clarisse   +11 more
core   +1 more source

Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

Brazilian Journal of Medical and Biological Research, 2014
Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored.
L.C. Jiang, S.Y. Huang, D.S. Zhang, S.H. Zhang, W.G. Li, P.H. Zheng, Z.W. Chen   +6 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Knockout of Beclin 1 inhibits GAS internalization.

, 2017
(A) Invasion rate of GAS in Beclin 1 KO cells. Both wild-type and Beclin 1 KO cells were infected with GAS (MOI = 100). At 1 h post-infection, cells were disrupted with distilled water and serial dilutions of cellular extracts were plated on THY agar ...
Hirotaka Toh (3639247), Chihiro Aikawa (221873), Ichiro Nakagawa (189496), Takashi Nozawa (221866), Shintaro Nakajima (3639244), Atsuko Minowa-Nozawa (3278481)   +5 more
core   +1 more source

Identification of novel small molecule Beclin 1 mimetics activating autophagy [PDF]

, 2017
Anti-apoptotic proteins Bcl-2 and Bcl-xL could block autophagy by binding to Beclin 1 protein, an essential inducer of autophagy. Compounds mimicking Beclin 1 might be able to disrupt Bcl-xL/2-Beclin 1 interaction, free out Beclin 1, and thus trigger ...
Jia Yu, Lewin, S.J., Aubé, Jeffrey, Liang Xu, Baiwang Sun, Lan, L., Roy, Anuradha, Xu, Liang, Lewin, Seth J., Philip Gao, John Karanicolas, Gao, P., Steven A. Rogers, Xiaoqing Wu, Roy, A., Gao, Philip, Xu, L., Yu, Jia, Karanicolas, John, Sun, B., Jeffrey Aubé, Seth J. Lewin, Lan, Lan, Anuradha Roy, Karanicolas, J., Lan Lan, Yu, J., Wu, X., Rogers, S.A., Sun, Baiwang, Aubé, J., Rogers, Steven A., Wu, Xiaoqing   +32 more
core   +1 more source

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1 [PDF]

Journal of Biological Chemistry, 2006
Intracellular accumulation of mutant Huntingtin with expanded polyglutamine provides a context-dependent cytotoxicity critical for the pathogenesis of Huntington disease (Everett, C. M., and Wood, N. W. (2004) Brain 127, 2385-2405). Here we demonstrate that the accumulation of mutant Huntingtin is highly sensitive to the expression of beclin 1, a gene ...
Shibata, Mamoru, Lu, Tao, Furuya, Tsuyoshi, Degterev, Alexei, Mizushima, Noboru, Yoshimori, Tamotsu, MacDonald, Marcy, Yankner, Bruce, Yuan, Junying   +8 more
openaire   +4 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

TRIM50 regulates Beclin 1 proautophagic activity

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2018
Autophagy is a catabolic process needed for maintaining cell viability and homeostasis in response to numerous stress conditions. Emerging evidence indicates that the ubiquitin system has a major role in this process. TRIMs, an E3 ligase protein family, contribute to selective autophagy acting as receptors and regulators of the autophagy proteins ...
Fusco C, Mandriani B, Di Rienzo M, Micale L, Malerba N, Cocciadiferro D, Sjottem E, Augello B, Squeo GM, Pellico MT, Jain A, Johansen T, Fimia GM, Merla G   +13 more
openaire   +3 more sources

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source