Results 91 to 100 of about 30,020,506 (258)
Evaluation of Beclin-1 and Bcl-2 interaction.
, 2013 A) EPCs were treated with CLC and RAD alone or in sequence and thereafter proteins were extracted. Then we performed western blot assay for the expression of the total Bcl2 and Beclin-1 proteins and immunoprecipitation of Bcl-2 and Beclin-1 subsequently ...
Nunzia D'Onofrio (482492) +10 more
core +1 more source
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Beclin-1-Dependent Autophagy Protects the Heart During Sepsis
, 2018 Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis have not been clearly defined.
Yang Xie +14 more
core +1 more source
Sorting Through the Roles of Beclin 1 in Microglia and Neurodegeneration [PDF]
Journal of Neuroimmune Pharmacology, 2014 Beclin 1 has a well-established role in regulating autophagy, a cellular degradation pathway. Although the yeast ortholog of beclin 1 (Atg6/Vps30) was discovered to also regulate vacuolar protein sorting nearly 30 years ago, the varied functions of beclin 1 in mammalian cells are only beginning to be sorted out.
Caitlin E, O'Brien, Tony, Wyss-Coray
openaire +2 more sources
Advanced Science, EarlyView.Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu +20 more
wiley +1 more source
The VMP1-Beclin 1 interaction regulates autophagy induction [PDF]
Scientific Reports, 2013 The Vacuole Membrane Protein 1 -VMP1- is a pancreatitis-associated transmembrane protein whose expression triggers autophagy in several human diseases. In the current study, we unveil the mechanism through which this protein induces autophagosome formation in mammalian cells.
Molejon, Maria Ines +4 more
openaire +3 more sources
Advanced Science, EarlyView.Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng +12 more
wiley +1 more source
, 2013 (A) Western blotting analysis of Beclin 1 and Bcl-xL expressions in ovarian carcinoma tissues (T) and adjacent normal ovarian tissues (N). (B) High expression of Beclin 1 was observed in epithelia cells of normal ovary by immunohistochemistry. (C) Highly-
Hui-Juan Qiu (5654461) +9 more
core +1 more source
The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond [PDF]
Trends in Cell Biology, 2010 An increasing body of research on autophagy provides overwhelming evidence for its connection to diverse biological functions and human diseases. Beclin 1, the first mammalian autophagy protein to be described, appears to act as a nexus point between autophagy, endosomal, and perhaps also cell death pathways.
Sarah F, Funderburk +2 more
openaire +2 more sources
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source