Results 91 to 100 of about 31,119 (206)
Cancer Science, EarlyView.OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan +8 more
wiley +1 more source
Beclin 1 or not Beclin 1... [PDF]
Autophagy, 2011 Tassula, Proikas-Cezanne +1 more
openaire +2 more sources
RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation
Cancer Science, EarlyView.RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu +10 more
wiley +1 more source
Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury
Neurobiology of Disease, 2008 Autophagy, an intracellular bulk degradation process of cellular constituents, plays a key role in cell homeostasis and can be induced by stresses, such as nutrient depletion, closed head injury or focal cerebral ischemia.
Silvia Carloni +2 more
doaj +1 more source
Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells
The FEBS Journal, EarlyView.D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono +3 more
wiley +1 more source
Autophagy-Related Beclin 1 and Head and Neck Cancers.
OncoTargets and therapy, 2020 Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression.
Hu,Yang-Jie +4 more
openaire +3 more sources
Inflammation‐Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF‐κB Crosstalk
International Endodontic Journal, EarlyView.ABSTRACT Background Inflammation critically determines dental pulp regenerative outcomes, with dental pulp stem cells (DPSCs) orchestrating tissue homeostasis through differentiation, self‐renewal and immunomodulation processes dynamically regulated by Wnt/β‐catenin and NF‐κB signaling crosstalk.
V. Rajasekar +4 more
wiley +1 more source
The Role of Oxidative Stress in Periodontitis
Journal of Periodontal Research, EarlyView.Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon +3 more
wiley +1 more source
Peri‐Implantitis and Periodontitis: Biological Convergence, Contextual Divergence
Journal of Periodontal Research, EarlyView.Periodontal and peri‐implant tissues differ and coincide in many aspects, from the clinical and radiological perspective, including histology, microbiology, and molecular markers. Thus, health and disease may also follow different and similar routes.
Pablo Galindo‐Moreno +6 more
wiley +1 more source
Muscle wasting in cancer cachexia: Mechanisms and the role of exercise
Experimental Physiology, EarlyView.Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento +2 more
wiley +1 more source