Results 91 to 100 of about 27,302,953 (278)

Prognostic value of Beclin 1, EGFR and ALK in non-squamous non-small cell lung cancer

Discover Oncology, 2022
Non-small cell lung cancer (NSCLC) is one of the most malignant tumors. The study was carried out to investigate the prognostic value of Beclin 1, EGFR and ALK for this cancer.
Yanhui Wan, Youhui Qian, Youyu Wang, Fuyuan Fang, Guodong Wu   +4 more
doaj   +1 more source

NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma

Molecular Oncology, 2020
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high NEK2 confers inferior survival in multiple myeloma (MM); thus, a better understanding of the mechanisms by which NEK2 induces drug resistance in MM is ...
Jiliang Xia, Yanjuan He, Bin Meng, Shilian Chen, Jingyu Zhang, Xuan Wu, Yinghong Zhu, Yi Shen, Xiang-ling Feng, Y. Guan, Chunmei Kuang, Jiaojiao Guo, Qian Lei, Yangbowen Wu, G. An, Guancheng Li, L. Qiu, F. Zhan, Wen Zhou   +18 more
semanticscholar   +1 more source

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease [PDF]

, 2017
Machado-Joseph disease or spinocerebellar ataxia type 3, the most common dominantly-inherited spinocerebellar ataxia, results from translation of the polyglutamine-expanded and aggregation prone ataxin 3 protein.
Albuquerque, David, Aveleira, Célia, Déglon, Nicole, Hirai, Hirokazu, Nascimento-Ferreira, Isabel, Nóbrega, Clévio, Onofre, Isabel, Pereira de Almeida, Luís, Vasconcelos-Ferreira, Ana   +8 more
core  

Basal ryanodine receptor activity suppresses autophagic flux [PDF]

, 2017
The inositol 1,4,5-trisphosphate receptors (IP3Rs) and intracellular Ca2+ signaling are critically involved in regulating different steps of autophagy, a lysosomal degradation pathway.
Bannai, Hiroko, Bootman, Martin D., Bultynck, Geert, Martinet, Wim, Mikoshiba, Katsuhiko, Nadif Kasri, Nael, Parys, Jan B., Pintelon, Isabel, Vervliet, Tim, Welkenhuyzen, Kirsten   +9 more
core   +2 more sources

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network [PDF]

, 2019
Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their
Alessio, Enrico, Bertoli, Alessandro, Buson, Lisa, Cagnin, Stefano, Chemello, Francesco, Grespi, Francesca, Lanfranchi, Gerolamo, Martini, Paolo, Massimino, Maria L, Millino, Caterina, Pacchioni, Beniamina, Peggion, Caterina, Romualdi, Chiara, Scorrano, Luca   +13 more
core   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Inflachromene inhibits autophagy through modulation of Beclin 1 activity [PDF]

Journal of Cell Science, 2018
ABSTRACT Autophagy is a central intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles, and regulation of autophagy is essential for homeostasis. HMGB1 is an important sepsis mediator when secreted and also functions as an inducer of autophagy by binding to Beclin 1.
Young Hun Kim, Man Sup Kwak, Jae Min Shin, Ria Aryani Hayuningtyas, Ji Eun Choi, Jeon-Soo Shin   +5 more
openaire   +3 more sources

Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

Brazilian Journal of Medical and Biological Research, 2014
Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored.
L.C. Jiang, S.Y. Huang, D.S. Zhang, S.H. Zhang, W.G. Li, P.H. Zheng, Z.W. Chen   +6 more
doaj   +1 more source

TREM2-dependent effects on microglia in Alzheimer\u27s Disease [PDF]

, 2018
Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.
Colonna, Marco, Ulland, Tyler K, Zhou, Yingyue   +2 more
core   +3 more sources