Results 101 to 110 of about 27,302,953 (278)

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

BECLIN 1 - Регулаторен протеин на автофагията

Varna Medical Forum, 2017
Изучаването на пропатогенните ефекти на автофагията е сравнително нова област на из- следване, показваща, че тя може да упражни многофункционални патогенетични роли, свър- зани с клетъчното оцеляване или смърт. Нару- шенията в процесите на автофагия предизвик- ват чувствителност към метаболитен стрес, геномно увреждане, неконтролирана клетъчна ...
Kameliya Bratoeva, Eleonora Dimitrova, Assia Konsoulova, Chavdar Bachvarov, Georgi Todorov, Kalin Kalchev, Nadezhda Stefanova, Ivan Donev   +7 more
openaire   +2 more sources

Involvement of Beclin 1 in Engulfment of Apoptotic Cells [PDF]

Journal of Biological Chemistry, 2012
Efficient apoptotic cell engulfment is important for both tissue homeostasis and immune response in mammals. In the present study, we report that Beclin 1 (a regulator of autophagy) is required for apoptotic cell engulfment. The engulfment process was largely abolished in Beclin 1 knock-out cells, and Beclin 1 knockdown significantly decreased ...
Akimitsu, Konishi, Satoko, Arakawa, Zhenyu, Yue, Shigeomi, Shimizu   +3 more
openaire   +2 more sources

Expression of the autophagic markers, light chain 3-I, light chain 3-II, and beclin 1, in vitiligo: a case–control study

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Autophagy is a lysosomal degradative process that is essential for the cell viability, homeostasis, and maintenance. Objective To measure microtubule-associated protein 1 light chain 3 (LC3)-I, LC3-II, and beclin 1 as indicators of autophagy ...
Ghada M El-Hanafy, Hanan R Nada, Laila A Rashed, Marwa F Mousa, Maha F Elmasry   +4 more
doaj   +1 more source

Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides. [PDF]

, 2019
Despite significant advances in the treatment of human immunodeficiency virus type-1 (HIV) infection, antiretroviral therapy only suppresses viral replication but is unable to eliminate infection. Thus, discontinuation of antiretrovirals results in viral
Campbell, Grant R, Fang, Ronnie H, Luk, Brian T, Spector, Stephen A, Wei, Xiaoli, Zhang, Gang, Zhang, Liangfang   +6 more
core  

Beclin 1-independent autophagy contributes to apoptosis in cortical neurons. [PDF]

, 2011
Neuronal autophagy is enhanced in many neurological conditions, such as cerebral ischemia and traumatic brain injury, but its role in associated neuronal death is controversial, especially under conditions of apoptosis. We therefore investigated the role
Clarke, P.G., Ginet, V., Grishchuk, Y., Puyal, J., Truttmann, A.C.   +4 more
core   +1 more source

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

An autophagy-independent function of Beclin 1 in cancer [PDF]

Molecular & Cellular Oncology, 2015
The involvement of Beclin 1 in cancer has been attributed primarily to its role in autophagy initiation. Our recent findings identify a novel, alternative mechanism by which Beclin 1 can impact tumor progression, through the regulation of growth factor receptor signaling.
Rohatgi, Rasika, Shaw, Leslie M.
openaire   +3 more sources

Short-term fenofibrate treatment improves ultrastructure of hepatocytes of old rats

Folia Histochemica et Cytobiologica, 2021
INTRODUCTION: Fenofibrate (FN) is a hypolipemic drug used for the treatment of mixed dyslipidemia. Since in our previous study FN administration to young and old rats adversely affected the serum activity of liver marker enzymes, we decided to examine ...
Adrian Zubrzycki, Agata Wronska, Agata Zauszkiewicz-Pawlak, Zbigniew Kmiec   +3 more
doaj   +1 more source

Depletion of Beclin-1 Due to Proteolytic Cleavage by Caspases in the Alzheimer\u27s Disease Brain [PDF]

, 2011
The Beclin-1 protein is essential for the initiation of autophagy and recent studies suggest this function may be compromised in Alzheimer’s disease (AD).
Brown, Raquel J., Harris, Jordan R., Masliah, Eliezer, Rohn, Troy T., Vandenabeele, Peter, Wirawan, Ellen   +5 more
core   +1 more source