Results 101 to 110 of about 30,020,506 (258)

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Beclin 1 expression in subtypes of ICC and ECC.

, 2013
Immunohistochemistry analysis of Beclin 1 expression in ICC (A) and ECC (B). Beclin 1 was lowly or moderately expressed in cancer cell cytoplasma, whereas highly expressed in the well differentiated tissue (original magnification, x100).
Qing-Hua Cao (489916), Zhan-Hong Chen (489922), Ming-Yuan Chen (329950), Xing Li (134367), Xiang-Bo Wan (329947), Qing Xia (114230), Dan-Yun Ruan (489919), Qu Lin (489918), Xiao-Kun Ma (489917), Tian-Tian Wang (68319), Lei Wang (6656), Chang-Chang Jia (410982), Min Dong (123378), Xin-Juan Fan (329948), Li Wei (203949), Xiang-Yuan Wu (329953), Jing-Yun Wen (489921), Ze-Xiao Lin (489920)   +17 more
core   +1 more source

The potency of native postbiotics and paraprobiotics in modulating inflammation by affecting the gut–kidney axis

Animal Models and Experimental Medicine, EarlyView.
Native postbiotics and paraprobiotics derived from Lactobacillus and Bifidobacterium strains were administered to dextran sulfate sodium–treated C57BL/6 mice to evaluate their impact on kidney inflammation via the gut–kidney axis. Histological analysis and quantitative polymerase chain reaction of autophagy‐related genes (atg5, atg7, atg12, atg13 ...
Fatemeh Haririzadeh Jouriani, Mahnaz Torfeh, Fatemeh Ashrafian, Niloofar Rezaie, Mohsen Mohammadi, Shadi Aghamohammad, Mahdi Rohani   +6 more
wiley   +1 more source

Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy [PDF]

, 2013
Autophagy is a degradation process that acts in response to environmental stressors. Recently, autophagy has been detected in normal term, preeclamptic and intrauterine growth-restricted placentas. The object of this work was to investigate the presence
Locci MT, LAZZERI, GLORIA, Guagnozzi M, LOCCI, MARIA TERESA FERNANDA, Lorella Battini, CHIELLINI, FEDERICA, Salerno MG, Dino Dinucci, Maria Giovanna Salerno, Filice ME, Chifenti B, Mariangela Guagnozzi, Barbara Chifenti, Maria Elena Filice, Dinucci D, Battini L.   +15 more
core   +1 more source

High Beclin-1 and ARID1A expression corelates with poor survival and high recurrence in intrahepatic cholangiocarcinoma: a histopathological retrospective study

BMC Cancer, 2019
Background Although surgical resection provides a cure for patients with intrahepatic cholangiocarcinoma (ICC), the risk of mortality and recurrence remains high.
Chao Bi, Mei Liu, Weiqi Rong, Fan Wu, Yang Zhang, Shengtao Lin, Yunhe Liu, Jianxiong Wu, Liming Wang   +8 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

BECLIN 1 - Регулаторен протеин на автофагията

, 2017
Изучаването на пропатогенните ефекти на автофагията е сравнително нова област на из- следване, показваща, че тя може да упражни многофункционални патогенетични роли, свър- зани с клетъчното оцеляване или смърт.
Bachvarov, Chavdar; Department of Diagnostics, Imaging and Radiotherapy, Medical University of Varna, Konsoulova, Assia; Clinic of Medical Oncology, UMHAT `St. Marina`, Department of Propedeutics of Internal Diseases, Medical University of Varna, Kalchev, Kalin; Department of General and Clinical Pathology, Medical University of Varna, Stefanova, Nadezhda; Department of General and Clinical Pathology, Medical University of Varna, Dimitrova, Eleonora; Clinic of Medical Oncology, UMHAT `St. Marina`, Department of Propedeutics of Internal Diseases, Medical University of Varna, Todorov, Georgi; Department of Diagnostics, Imaging and Radiotherapy, Medical University of Varna, Donev, Ivan; Clinic of Medical Oncology, UMHAT `St. Marina`, Department of Propedeutics of Internal Diseases, Medical University of Varna, Bratoeva, Kameliya; Department of Physiology and pathophysiology, Division of pathophysiology, Medical University of Varna   +7 more
core   +3 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death

Neurobiology of Disease, 2009
Autophagy is a degradation of the cytoplasm and it induces autophagic cell death in several neurodegenerative conditions. Beclin 1, a Bcl-2-interacting protein, is known to be a promoter of autophagy.
Haruo Kanno, Hiroshi Ozawa, Akira Sekiguchi, Eiji Itoi   +3 more
doaj   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source