Results 81 to 90 of about 30,020,506 (258)

Expression levels and clinical significance of autophagy related proteins in placenta tissues of pregnant women with fetal growth restriction [PDF]

Jichu yixue yu linchuang
Objective To explore the expression and clinical significance of autophagy related proteins Beclin-1, microtubule-associated protein 1 light chain 3(LC3) in placenta tissues of pregnant women with fetal growth restriction(FGR).
ZHANG Yuling, ZHANG Ke, XU Ting, ZHANG Qing
doaj   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

The effects of overexpressing Beclin 1 and Beclin 2 in autophagy and cell survival.

, 2015
(A) SAS cells were transfected with control plasmid, plasmids expressing flag-tagged Beclin 1 (B1) or Beclin 2 (B2). At 24 h posttransfection, cells were treated with Earle’s balanced salt solution (EBSS) for 1 h starvation.
Fang-Hui Lee (818769), Chien-Hui Hung (431717), Cheng-Nan Chen (663629), Jing-Lan Liu (818766), Jrhau Lung (818767), Fen-Fen Chen (648329), Ying-Chou Lu (818770), Cheng-Hsing Lo (818768), Shun-Fu Chang (184287)   +8 more
core   +1 more source

Beclin 1 Biology and its Role in Heart Disease [PDF]

Current Cardiology Reviews, 2015
Macroautophagy (hereafter termed autophagy) is a highly evolutionarily conserved pathway that degrades intracellular components such as damaged organelles in lysosome. Autophagy occurs at low basal levels in virtually all types of cells, which is required for the maintenance of cellular homeostasis. Beclin 1 protein, encoded by the beclin 1 gene, plays
Zhu, Hongxin, He, Lin
openaire   +2 more sources

Morphine induces Beclin 1-and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus

, 2010
Chronic exposure to morphine can induce drug addiction and neural injury, but the exact mechanism is not fully understood. Here we show that morphine induces autophagy in neuroblastoma SH-SY5Y cells and in the rat hippocampus.
Sui, Nan, Gao, Ping, Xu, Lin, Wang, Xiaohui, Chen, Ming, Wang, Dongmei, Zhao, Lixia, Jin, Haijing, Chen, Quan, Xiao, Weiming, Zhu, Yushan, Rao, Guanhua, 隋南   +12 more
core   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1

, 2019
Intracellular accumulation of mutant Huntingtin with expanded polyglutamine provides a context-dependent cytotoxicity critical for the pathogenesis of Huntington disease (Everett, C. M., and Wood, N. W. (2004) Brain 127, 2385-2405).
Mizushima, Noboru, Degterev, Alexei, Yankner, Bruce, Yuan, Junying, Lu, Tao, Furuya, Tsuyoshi, Yoshimori, Tamotsu, MacDonald, Marcy, Shibata, Mamoru   +8 more
core   +1 more source

Beclin 1 bridges autophagy, apoptosis and differentiation [PDF]

Autophagy, 2008
Beclin 1 is a critical component in the class III PI3 kinase complex (PI3KC3) that induces the formation of autophagosomes in mammalian systems. Autophagic triggers upregulate Beclin 1, which in turn binds to PI3KC3 or Bcl-X(L) to form complexes of Beclin 1-PI3KC3 or Beclin 1-Bcl-X(L) that are physically and functionally independent from each other ...
openaire   +2 more sources

Polyglutamine tracts regulate beclin 1-dependent autophagy [PDF]

Nature, 2017
Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also varies.
Ashkenazi, A, Bento, CF, Ricketts, T, Vicinanza, M, Siddiqi, F, Pavel, M, Squitieri, F, Hardenberg, MC, Imarisio, S, Menzies, FM, Rubinsztein, DC   +10 more
openaire   +2 more sources

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source