Results 121 to 130 of about 27,302,953 (278)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules [PDF]

Molecular Cell, 2012
Bim is a proapoptotic BH3-only Bcl-2 family member. In response to death stimuli, Bim dissociates from the dynein light chain 1 (DYNLL1/LC8), where it is inactive, and can then initiate Bax/Bak-mediated mitochondria-dependent apoptosis. We found that Bim depletion increases autophagosome synthesis in cells and in vivo, and this effect is inhibited by ...
Luo, Shouqing, Garcia-Arencibia, Moises, Zhao, Rui, Puri, Claudia, Toh, Pearl P.C., Sadiq, Oana, Rubinsztein, David C.   +6 more
openaire   +3 more sources

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia.

JCI Insight, 2020
Autosis is a distinct form of cell death that requires both autophagy genes and the Na+,K+-ATPase pump. However, the relationship between the autophagy machinery and Na+,K+-ATPase is unknown.
Álvaro F. Fernández, Yang Liu, V. Ginet, Mingjun Shi, Jihoon Nah, Z. Zou, Anwu Zhou, B. Posner, Guanghua Xiao, M. Tanguy, V. Paradis, J. Sadoshima, P. Rautou, J. Puyal, M. Hu, B. Levine   +15 more
semanticscholar   +1 more source

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells [PDF]

, 2018
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK)
Contreras Bernal, Laura, Cruz Díaz, Jesús de la, Gallego, Paloma, González, Raúl, Navarro Villarán, Elena, Ordóñez, Raquel, Rodríguez Arribas, M., Rodríguez Hernández, María A., Rosa, Ángel J. de la   +8 more
core   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Prognostic significance of Beclin 1 in intrahepatic cholangiocellular carcinoma [PDF]

Autophagy, 2011
Autophagy enables cells to recycle long-lived proteins or damaged organelles. Beclin 1 plays important roles in autophagy, differentiation, apoptosis and the development and progression of cancer, but the expression of Beclin 1 and its possible role in primary intrahepatic cholangiocarcinoma (ICC) has not been reported yet.
Li-Wei, Dong, Yu-Jie Hou, Hou, Ye-Xiong, Tan, Liang, Tang, Yu-Fei, Pan, Min, Wang, Hong-Yang, Wang   +6 more
openaire   +2 more sources

MIR376A is a regulator of starvation-induced autophagy [PDF]

, 2013
Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Ali Kosar, B Ravikumar, B Teferedegne, BS Zhao, C le Sage, C Macedo, C Nakada, CJ Foley, D Gozuacik, D Nachmani, Deniz Gulfem Ozturk, Devrim Gozuacik, DJ Klionsky, E Chan, EJ Lee, F Wang, G Bjorkoy, G Korkmaz, G Russo, Gozde Korkmaz, H Seitz, H Siomi, HW Platta, I Tanida, J Hildebrand, J Winter, JS Lee, K Breving, K Duskova, KA Tekirdag, Kumsal Ayse Tekirdag, L Zehavi, LB Frankel, LB Frankel, LM Silva, M Kircher, MD Abramoff, N Mizushima, N Mizushima, N Mizushima, O Oral, Osman Ugur Sezerman, P Mestdagh, PM Voorhoeve, R Faraonio, R Scherz-Shouval, RC Russell, RC Wang, RL Skalsky, S Romao, S Sinha, Sebastien Pfeffer, T Wang, TG McDaneld, V Ambros, V Deretic, X Liu, X Zhang, Y Kabeya, Y Kawahara, Y Ohsumi   +60 more
core   +3 more sources

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity

Biology, 2020
Simple Summary We described the existence of an integrated Beclin 1, TLR9, and SIRT3 network involving autophagy, oxidative stress, and mitochondria that is essential for empagliflozin to protect against doxorubicin toxicity in the heart.
Chao-Yung Wang, Chun-Chi Chen, Mei-Hsiu Lin, Hui-Ting Su, M. Ho, Jih-Kai Yeh, Ming-Lung Tsai, I. Hsieh, M. Wen   +8 more
semanticscholar   +1 more source

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source