Results 121 to 130 of about 31,119 (206)
Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Food and medicine homologous (FMH) plants and their bioactive compounds exhibit potential osteoprotective effects through multiple complementary mechanisms, including estrogen‐like signaling, attenuation of oxidative stress, modulation of the gut microbiota–bone axis, and regulation of autophagy.
Long Zhao +4 more
wiley +1 more source
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, Volume 2, Issue 2, June 2026.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.ABSTRACT mRNA‐based therapeutics offer significant potential for cancer treatment owing to their ability to induce transient, non‐integrating expression of therapeutic proteins. However, effective and tumour‐specific delivery remains a major barrier.
Dandan Wang +8 more
wiley +1 more source
Iranian Journal of Reproductive Medicine, 2015 Background: The pathogenesis of Gestational Trophoblastic Disease (GTD) is not clearly known. Objective: In this study, immunoexpression of proteins Bcl-2 and Beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the ...
Teresa Liliana Wargasetia +4 more
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JOR SPINE, Volume 9, Issue 2, June 2026.LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan +7 more
wiley +1 more source
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.
The Journal of biological chemistry, 2007 Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor Beclin 1 has been proposed to coordinate both apoptosis and autophagy through direct interaction with anti-apoptotic family members Bcl-2 and/or Bcl-X(L).
Adam, Oberstein +2 more
openaire +1 more source
MedComm, Volume 7, Issue 6, June 2026.This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
Encephalopathy: Cause, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 6, June 2026.Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv +7 more
wiley +1 more source
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao +4 more
wiley +1 more source