Results 131 to 140 of about 30,020,506 (258)

Autophagy-independent enhancing effects of Beclin 1 on cytotoxicity of ovarian cancer cells mediated by proteasome inhibitors

BMC Cancer, 2012
Background The ubiquitin-proteasome system and macroautophagy (hereafter referred to autophagy) are two complementary pathways for protein degradation. Emerging evidence suggests that proteasome inhibition might be a promising approach for tumor therapy.
Liu Chuan, Yan Xu, Wang Hua-Qin, Gao Yan-Yan, Liu Juanjuan, Hu Zhenhua, Liu Dawo, Gao Jian, Lin Bei   +8 more
doaj   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source

Tetracycline inhibiting the protein levels of LC3 and Beclin 1.

, 2012
(A) LC3 and Beclin 1 in brain tissues detected by western blotting using β-actin as loading control. (B) Relative density of LC3 II/LC3 I and Beclin 1. (C) LC3 detected by immunofluorescence. Scale bar = 5 µm.
Jianwu Dai (122949), Gelin Xu (122945), Yongjun Jiang (122936), Juehua Zhu (122941), Xinfeng Liu (122953), Li Wu (120770)   +5 more
core   +1 more source

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

Neurobiology of Disease, 2011
The Beclin-1 protein is essential for the initiation of autophagy, and recent studies suggest this function may be compromised in Alzheimer's disease (AD).
Troy T. Rohn, Ellen Wirawan, Raquel J. Brown, Jordan R. Harris, Eliezer Masliah, Peter Vandenabeele   +5 more
doaj   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

, 2011
Beclin 1, a subunit of the class III phosphatidylinositol 3-kinase complex, is a tumour suppressor with a central role in endocytic trafficking, cytokinesis and the cross-regulation between autophagy and apoptosis.
Hilde Abrahamsen, Sigrid B. Thoresen, Harald W. Platta, Harald Stenmark   +3 more
core   +1 more source

Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer [PDF]

, 2014
Autophagy is dysregulated in cancer and might be involved in ovarian carcinogenesis. BECLIN-1, a protein that interacts with either BCL-2 or PI3k class III, plays a critical role in the regulation of both autophagy and cell death.
Giuseppina Nicotra, ALABISO, Oscar, Nicola Fusco, Isidoro C, Katsaros D, Valente G, G. Valente, VALENTE, Guido, F. Morani, C. Isidoro, O. Alabiso, Benedetto C, Nicotra G, Alabiso O, Fusco N, D. Katsaros, C. Benedetto, G. Nicotra, Titone R, Riccardo Arisio, Peracchio C, R. Arisio, Claudia Peracchio, ISIDORO, Ciro, Rossella Titone, Chiara Benedetto, Dyonissios Katsaros, Morani F, R. Titone, Federica Morani, N. Fusco, Arisio R, C. Peracchio   +32 more
core   +1 more source

Autophagy-Related Beclin 1 and Head and Neck Cancers.

OncoTargets and therapy, 2020
Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression.
Hu,Yang-Jie, Zhong,Jiang-Tao, Gong,Liang, Zhang,Si-Cong, Zhou,Shui-Hong   +4 more
openaire   +3 more sources

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6‐Mediated Deacetylation

Phytotherapy Research, EarlyView.
AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue, Chen Yong, Xinran Wang, Yang Shu, Min Yao, Yongfei Yu, Yubai Xue, Rong Deng, Tianlu Chu, Weiwei Tao, Min Zhao, Enchao Zhou   +11 more
wiley   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source