Results 131 to 140 of about 27,302,953 (278)
Cell Death and Disease, 2020 Gastrointestinal stromal tumors (GISTs), the most widespread type of sarcoma, contain driver gene mutations predominantly of receptor tyrosine kinase and platelet-derived growth factor receptor alpha.
Wei Chen +10 more
semanticscholar +1 more source
PREP-modifikaatioiden vaikutus autofagiaan [PDF]
, 2017 Autophagy is a pathway for cells to degrade intracellular components that are no longer needed or are detrimental for the cells. It is essential for cell homeostasis and survival and has been related to various diseases and pathophysiology.
Huovila, Tiina
core
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li +4 more
wiley +1 more source
p65/RelA binds and activates the beclin 1 promoter [PDF]
Autophagy, 2009 We unveiled novel p65/RelA consensus sites in the promoter of the beclin 1 gene and demonstrate that p65/RelA positively modulates canonical autophagy in various human cell lines both under basal conditions and upon induction by ceramide. Interestingly, we find that T cell receptor-dependent activation of Jurkat cells triggers an increase in the ...
COPETTI T +2 more
openaire +3 more sources
ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase
Nature Cell Biology, 2013 Autophagy is the primary cellular catabolic program activated in response to nutrient starvation. Initiation of autophagy, particularly by amino-acid withdrawal, requires the ULK kinases.
R. Russell +9 more
semanticscholar +1 more source
Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. [PDF]
, 2013 Aged (>50 years old) human immunodeficiency virus (HIV) patients are the fastest-growing segment of the HIV-infected population in the USA and despite antiretroviral therapy, HIV-associated neurocognitive disorder (HAND) prevalence has increased or ...
Adame, Anthony +10 more
core +2 more sources
The Journal of Pathology, EarlyView.Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song +6 more
wiley +1 more source
LC3A, LC3B and Beclin-1 Expression in Gastric Cancer [PDF]
Anticancer Research, 2018 The current study examined the key proteins involved in autophagosome formation and their prognostic role in gastric cancer.Paraffin-embedded tissues from 121 consecutive patients treated with surgery for gastric cancer were analyzed immunohistochemically for the expression of autophagic proteins microtubule-associated proteins 1A/1B light chain 3A and
Alexandra, Giatromanolaki +4 more
openaire +2 more sources
AJP - Renal Physiology, 2020 Klotho and beclin 1-driven autophagy extends life. We examined the role of beclin 1 in modifying acute kidney injury (AKI), and whether beclin 1 mediates Klotho's renoprotective action in AKI.
Peng Li +6 more
semanticscholar +1 more source
Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis
Andrology, EarlyView.ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan +10 more
wiley +1 more source