Results 141 to 150 of about 30,020,506 (258)
A comprehensive review of cancer‐induced cardiac wasting
British Journal of Pharmacology, EarlyView.Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena +5 more
wiley +1 more source
Beclin 1+/− has no effect on cell death, proliferation and ROS levels in thymocytes.
, 2013 A) Isolated thymocytes from mice of the indicated genotypes were treated with Dex (1μM), using Q-VD-OPh (50 μM) as positive control for Caspase inhibition. Viability was determined over time. The means ± SD of at least 2 mice per group are shown.
Sih-han Wang (351494) +3 more
core +1 more source
Cancer Science, EarlyView.Spatial multi‐omics mapping of hepatic angiomyolipoma reveals that PEComas tightly co‐localize with endothelial cells, which drive autophagic flux in adjacent tumor cells via a paracrine PDGFD–PDGFRB–Ras axis, establishing a compensatory survival network that operates in parallel to canonical TSC–mTOR defects.
Xinyang Liu +9 more
wiley +1 more source
Characterization of a conditional mouse model lacking Beclin-1 in Schwann cells
reservedBeclin-1 è una proteina studiata per il suo ruolo nell'autofagia e traffico endosomiale, oltre che come oncosoppressore. Nel laboratorio in cui ho svolto il lavoro di tesi è stato generato un modello murino knockout condizionale (cKO) per ...
ALBERTON, ANNA
core
ROC curves analysis of Beclin 1 cutoff score.
, 2013 (A) and (B) showed the Beclin 1 cutoff points for overall survival and progression-free survival in the training set. At each immunohistochemical score, the sensitivity and specificity for the outcome being studied was plotted, thus generating a ROC ...
Weihua Zhou (19271) +11 more
core +1 more source
The FEBS Journal, EarlyView.A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong +6 more
wiley +1 more source
Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis
Journal of Diabetes Investigation, EarlyView.ABSTRACT Kidney disease is a major microvascular complication of diabetes, affecting approximately 40% of individuals with diabetes, and is a leading cause of end‐stage renal disease. Besides the functional consequences of hyperglycemia; hemodynamic alterations are well understood.
Deenadhayalan Ashok +3 more
wiley +1 more source
The Role of Oxidative Stress in Periodontitis
Journal of Periodontal Research, EarlyView.Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon +3 more
wiley +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source