Results 51 to 60 of about 30,020,506 (258)
Ecotoxicology and Environmental Safety, 2022 Arsenite is a toxic metalloid that causes various adverse effects in brain. However, the underlying mechanisms of arsenite-induced neurotoxicity remain poorly understood.
Hongmei Zhou +10 more
doaj +1 more source
Autophagy, Beclin 1, and Their Relation To Oncogenesis [PDF]
Laboratory Medicine, 2008 Autophagy is a lysosomal degradation pathway for cytoplasmic material. Recent studies have demonstrated that autophagy is related closely to the occurrence and development of tumor. Beclin 1 was the first identified mammalian gene with a role in mediating autophagy.
Yang Sun, Zhi-Lan Peng
openaire +1 more source
Autophagy plays a protective role against Trypanosoma cruzi infection in mice
Virulence, 2019 Autophagy is a catabolic pathway required for cellular and organism homeostasis. Autophagy participates in the innate and adaptive immune responses at different levels.
Ana Florencia Casassa +4 more
doaj +1 more source
Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG. [PDF]
PLoS ONE, 2017 Anti-apoptotic Bcl-2 and Bcl-xL are proposed to regulate starvation-induced autophagy by directly interacting with Beclin 1. Beclin 1 is also thought to be involved in multiple vesicle trafficking pathways such as endocytosis by binding to Atg14L and ...
Shintaro Nakajima +5 more
doaj +1 more source
Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death
Neurobiology of Disease, 2008 Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic contents which seems to be implicated in a variety of physiological and pathological conditions relevant to neurological diseases.
A. Rami, A. Langhagen, S. Steiger
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Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells. [PDF]
PLoS ONE, 2014 Beclin 1 interacts with UV-irradiation-resistance-associated gene (UVRAG) to form core complexes that induce autophagy. While cells with defective autophagy are prone to genomic instability that contributes to tumorigenesis, it is unknown whether Beclin1
Jae Myung Park +4 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Virology Journal, 2019 Background MicroRNAs (miRNAs) is increasingly recognized as an important element in regulating virus-host interactions. Our previous results showed that cellular miR-30a-5p was significantly downregulated after duck enteritis virus (DEV) infection cell ...
Xianglong Wu +19 more
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Prognostic value of Beclin 1, EGFR and ALK in non-squamous non-small cell lung cancer
Discover Oncology, 2022 Non-small cell lung cancer (NSCLC) is one of the most malignant tumors. The study was carried out to investigate the prognostic value of Beclin 1, EGFR and ALK for this cancer.
Yanhui Wan +4 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source