Results 51 to 60 of about 31,119 (206)

Downregulation of microRNA-30a-5p contributes to the replication of duck enteritis virus by regulating Beclin-1-mediated autophagy

Virology Journal, 2019
Background MicroRNAs (miRNAs) is increasingly recognized as an important element in regulating virus-host interactions. Our previous results showed that cellular miR-30a-5p was significantly downregulated after duck enteritis virus (DEV) infection cell ...
Xianglong Wu, Renyong Jia, Mingshu Wang, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Qiao Yang, Ying Wu, Zhongqiong Yin, Shaqiu Zhang, Juan Huang, Ling Zhang, Yunya Liu, Yanling Yu, Leichang Pan, Bin Tian, Mujeeb Ur Rehman, Xiaoyue Chen, Anchun Cheng   +19 more
doaj   +1 more source

Prognostic value of Beclin 1, EGFR and ALK in non-squamous non-small cell lung cancer

Discover Oncology, 2022
Non-small cell lung cancer (NSCLC) is one of the most malignant tumors. The study was carried out to investigate the prognostic value of Beclin 1, EGFR and ALK for this cancer.
Yanhui Wan, Youhui Qian, Youyu Wang, Fuyuan Fang, Guodong Wu   +4 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1 [PDF]

Journal of Biological Chemistry, 2006
Intracellular accumulation of mutant Huntingtin with expanded polyglutamine provides a context-dependent cytotoxicity critical for the pathogenesis of Huntington disease (Everett, C. M., and Wood, N. W. (2004) Brain 127, 2385-2405). Here we demonstrate that the accumulation of mutant Huntingtin is highly sensitive to the expression of beclin 1, a gene ...
Shibata, Mamoru, Lu, Tao, Furuya, Tsuyoshi, Degterev, Alexei, Mizushima, Noboru, Yoshimori, Tamotsu, MacDonald, Marcy, Yankner, Bruce, Yuan, Junying   +8 more
openaire   +4 more sources

Autophagy plays a protective role against Trypanosoma cruzi infection in mice

Virulence, 2019
Autophagy is a catabolic pathway required for cellular and organism homeostasis. Autophagy participates in the innate and adaptive immune responses at different levels.
Ana Florencia Casassa, María Cristina Vanrell, María Isabel Colombo, Roberta A. Gottlieb, Patricia Silvia Romano   +4 more
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Beclin 1 bridges autophagy, apoptosis and differentiation [PDF]

Autophagy, 2008
Beclin 1 is a critical component in the class III PI3 kinase complex (PI3KC3) that induces the formation of autophagosomes in mammalian systems. Autophagic triggers upregulate Beclin 1, which in turn binds to PI3KC3 or Bcl-X(L) to form complexes of Beclin 1-PI3KC3 or Beclin 1-Bcl-X(L) that are physically and functionally independent from each other ...
openaire   +2 more sources

Polyglutamine tracts regulate beclin 1-dependent autophagy [PDF]

Nature, 2017
Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also varies.
Ashkenazi, A, Bento, CF, Ricketts, T, Vicinanza, M, Siddiqi, F, Pavel, M, Squitieri, F, Hardenberg, MC, Imarisio, S, Menzies, FM, Rubinsztein, DC   +10 more
openaire   +2 more sources

Expression of the autophagic markers, light chain 3-I, light chain 3-II, and beclin 1, in vitiligo: a case–control study

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Autophagy is a lysosomal degradative process that is essential for the cell viability, homeostasis, and maintenance. Objective To measure microtubule-associated protein 1 light chain 3 (LC3)-I, LC3-II, and beclin 1 as indicators of autophagy ...
Ghada M El-Hanafy, Hanan R Nada, Laila A Rashed, Marwa F Mousa, Maha F Elmasry   +4 more
doaj   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source