Results 51 to 60 of about 27,302,953 (278)
Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma. [PDF]
PLoS ONE, 2013 It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear.In the present
Huan-Xin Lin +9 more
doaj +1 more source
Macrophage autophagy in atherosclerosis [PDF]
, 2013 Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R. +5 more
core +2 more sources
Beclin 1 Complex in Autophagy and Alzheimer Disease [PDF]
Archives of Neurology, 2010 Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be reduced in patients with Alzheimer disease. This review summarizes the current research data that link disturbances in autophagy, a cellular degradation and maintenance pathway, to the development of Alzheimer disease and related neurodegenerative diseases.
Philipp A, Jaeger, Tony, Wyss-Coray
openaire +2 more sources
Genetic and epigenetic silencing of the
BMC Cancer, 2010 Background Beclin 1, an important autophagy-related protein in human cells, is involved in cell death and cell survival. Beclin 1 mapped to human chromosome 17q21. It is widely expressed in normal mammary epithelial cells.
Wu Yiqing +5 more
doaj +1 more source
Nature Communications, 2021 Host cells use several anti-bacterial pathways to defend against pathogens. Here, using a uropathogenic Escherichia coli (UPEC) infection model, we demonstrate that bacterial infection upregulates RhoB, which subsequently promotes intracellular bacteria ...
Chunhui Miao +10 more
semanticscholar +1 more source
Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]
, 2016 Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C +6 more
core +1 more source
Beclin-1 as a neutrophil-specific immune checkpoint [PDF]
Journal of Clinical Investigation, 2019 Neutrophils are early wound healing and inflammation regulators that, due to functional plasticity, can adopt either pro- or antitumor functions. Until recently, beclin-1 was a protein known mainly for its role as a critical regulator of autophagy. In this issue of the JCI, Tan et al.
Yu-Lin Su, Marcin Kortylewski
openaire +2 more sources
Journal of Medicinal Chemistry, 2021 Beclin 1 is an essential autophagy gene and a haploinsufficient tumor suppressor. Beclin 1 is the scaffolding member of the Class III phosphatidylinositol-3-kinase complex (PI3KC3) and recruits two positive regulators Atg14L and UVRAG through its coiled ...
Qifan Yang +9 more
semanticscholar +1 more source
Autophagy and rheumatoid arthritis: Current knowledges and future perspectives [PDF]
, 2018 Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens ...
Alessandri, Cristiano +10 more
core +2 more sources
Intestinal epithelial CGAS dampens inflammation by upregulating autophagy
Autophagy Reports, 2022 The pathogenesis of intestinal inflammation involves a complex network of cell signaling pathways. CGAS (cyclic GMP-AMP synthase) is a cytoplasmic DNA sensor that is most known for upregulating interferon-mediated inflammation.
Elizabeth A. Novak +5 more
doaj +1 more source