Results 31 to 40 of about 27,302,953 (278)

Common and divergent functions of Beclin 1 and Beclin 2 [PDF]

Cell Research, 2013
In a recent paper published in Cell, He and colleagues reported the identification and functional characterization of Beclin 2, a mammal-specific homolog of the evolutionarily conserved autophagy-regulatory and oncosuppressive factor Beclin 1. In spite of a non-negligible degree of sequence identity, Beclin 1 and Beclin 2 differ from each other in ...
Lorenzo, Galluzzi, Guido, Kroemer
openaire   +2 more sources

Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy

Frontiers in Cell and Developmental Biology, 2022
A growing body of evidence suggests that neutrophil extracellular traps (NETs) critically contribute to the development of atherosclerosis. However, the detailed mechanism of how NETs promote atherogenesis remains unknown.
Masataka Sano, Y. Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Natsuko Tamura, K. Hirao, M. Isobe, T. Sasano   +7 more
semanticscholar   +1 more source

Regulation of Beclin 1 in autophagy [PDF]

Autophagy, 2009
Class III phosphatidylinositol 3-kinase (PI3KC3) plays a pleiotropic role in autophagy and protein sorting pathways. The human core complex of PI3KC3 consists of three major components including PI3KC3/hVps34, p150 and Beclin 1. How the specificity of PI3KC3 complex is derived towards autophagy is not clear. Utilizing a sequential affinity purification
Qiming, Sun, Weiliang, Fan, Qing, Zhong
openaire   +2 more sources

Cyclic GMP‐AMP synthase contributes to epithelial homeostasis in intestinal inflammation via Beclin‐1‐mediated autophagy

The FASEB Journal, 2022
Inflammatory bowel disease (IBD) represents a set of idiopathic and chronic inflammatory diseases of the gastrointestinal tract. Central to the pathogenesis of IBD is a dysregulation of normal intestinal epithelial homeostasis.
Sidrah Khan, H. Mentrup, Elizabeth A. Novak, V. Siow, Qian Wang, Erin C. Crawford, C. Schneider, Thomas E Comerford, B. Firek, Matt B Rogers, P. Loughran, Michael J. Morowitz, K. Mollen   +12 more
semanticscholar   +1 more source

Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer. [PDF]

PLoS ONE, 2013
Beclin 1, a key regulator of autophagy, has been found to be aberrantly expressed in a variety of human malignancies. Herein, we employed immunohistochemistry (IHC) to detect the protein expression of Beclin 1 in non-small cell lung cancer (NSCLC) and ...
Weihua Zhou, Caifeng Yue, Jinyun Deng, Ronghuan Hu, Jie Xu, Long Feng, Qiongyu Lan, Wenfeng Zhang, Dexiang Ji, Jianbing Wu, Quentin Liu, Anwen Liu   +11 more
doaj   +1 more source

Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway

JCI Insight, 2021
The mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of acetaldehyde and endogenous lipid aldehydes. Approximately 40% of East Asians, accounting for 8% of the human population, carry the E504K mutation in ALDH2 that ...
Tonghui Xu, Jialin Guo, Maozeng Wei, Jiali Wang, Kehui Yang, C. Pan, J. Pang, L. Xue, Qiuhuan Yuan, Mengyang Xue, Jian Zhang, Wentao Sang, Tangxing Jiang, Yuguo Chen, Feng Xu   +14 more
semanticscholar   +1 more source

Neurodegeneration Induces Upregulation of Beclin 1 [PDF]

Autophagy, 2006
Autophagy, a bulk degradation of subcellular constituents, is activated in normal cell growth and development, and represents the major pathway by which the cell maintains a balance between protein synthesis and protein degradation. Autophagy was documented in several neurodegenerative diseases, and under stress conditions the autophagic process can ...
Shlomit, Erlich, Esther, Shohami, Ronit, Pinkas-Kramarski   +2 more
openaire   +2 more sources

JNK initiates Beclin-1 dependent autophagic cell death against Akt activation.

Experimental Cell Research, 2022
ABT-199, a specific inhibitor of the Bcl-2 protein, is widely used in clinical trials for hematological tumors and rarely applied to the research of solid tumors.
Chao Zeng, Zhixuan Zhang, W. Luo, Li-yang Wang, Hang Zhou, Chunlai Nie   +5 more
semanticscholar   +1 more source

Autophagy processes are dependent on EGF receptor signaling [PDF]

, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina, Caruso, Marika, Conti, Pio, Flati, Vincenzo, Iuliis, Vincenzo De, Lanuti, Paola, Marino, Antonio, Marricareda, Valeria, Martinotti, Stefano, Marynuk, Anna, Talora, Claudio, Toniato, Elena, Ursi, Sebastiano   +12 more
core   +1 more source

Autophagy induction regulates influenza virus replication in a time-dependent manner [PDF]

, 2017
Autophagy plays a key role in host defence responses against microbial infections by promoting degradation of pathogens and participating in acquired immunity.
Abdoli, Asghar, Bamdad, Taravat, Feizi, Amir, Feizi, Neda, Fotouhi, Fatemeh, Jamali, Abbas, Mehrbod, Parvaneh, Nasrollahi Nargesabad, Reza, Ollah Jazaeri, Ehsan, Romani, Bizhan, Saleh, Maryam, Shokouhi Targhi, Hadiseh, Soleimanjahi, Hoorieh   +12 more
core   +1 more source