Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma. [PDF]
PLoS ONE, 2013 It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear.In the present
Huan-Xin Lin +9 more
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Влияние стрессоустойчивости на экспрессию проаутофагического белка Beclin-1 в миокарде после экспериментального ушиба сердца [PDF]
, 2023 Objective. Evaluation of myocardial expression of the pro-autophagic protein Beclin-1 after cardiac contusion in experimental animals with different stress resistance.Materials and methods. The study included 68 white mongrel male rats weighing 250–300 g.
С. И. Мозговой +9 more
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An autophagy-independent function of Beclin 1 in cancer [PDF]
Molecular & Cellular Oncology, 2015 The involvement of Beclin 1 in cancer has been attributed primarily to its role in autophagy initiation. Our recent findings identify a novel, alternative mechanism by which Beclin 1 can impact tumor progression, through the regulation of growth factor receptor signaling.
Rohatgi, Rasika, Shaw, Leslie M.
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Heliyon, 2023 Radioresistance is the major factor of glioblastoma multiforme (GBM) treatment failure and relapse. Hypoxia and autophagy are linked to radioresistance and poor prognosis in solid tumors, but mechanisms remain unknown.
Jielin Wei +8 more
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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy [PDF]
, 2005 SummaryApoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis, development, and disease.
Sophie Pattingre +17 more
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MIR376A is a regulator of starvation-induced autophagy [PDF]
, 2013 Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Gozuacik Devrim +25 more
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VCP/p97 regulates Beclin-1-dependent autophagy initiation [PDF]
, 2021 Autophagy is an essential cellular process that removes harmful protein species, and autophagy upregulation may be able to protect against neurodegeneration and various pathogens.
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Beclin-1–Dependent Autophagy Improves Outcomes of Pneumonia-Induced Sepsis
Frontiers in Cellular and Infection Microbiology, 2021 ObjectiveWe previously demonstrated that promoting Beclin-1–dependent autophagy is cardiac protective during endotoxemia shock, suggesting that autophagy-based approaches may become a promising therapeutic strategy for sepsis.
Azadeh Nikouee +4 more
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Upregulation of Beclin 1 in the ischemic penumbra [PDF]
Autophagy, 2008 Here we discuss the probable role of autophagy in cerebral ischemia based on our own recent data and the literature. We examined the protein level of Beclin 1 (Bcl-2 interacting protein) and microtubule-associated protein 1 light chain 3 (LC3) which were previously found to promote autophagy.
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Expression of beclin-1 in the microenvironment of invasive ductal carcinoma of the breast: correlation with prognosis and the cancer-stromal interaction. [PDF]
PLoS ONE, 2015 We examined the pathobiological properties of beclin-1, which is a key regulator of autophagosome formation in invasive ductal carcinoma of the breast, with a particular focus on the cancer microenvironment.
Akemi Morikawa +6 more
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