Results 31 to 40 of about 31,119 (206)
Intestinal epithelial CGAS dampens inflammation by upregulating autophagy
Autophagy Reports, 2022 The pathogenesis of intestinal inflammation involves a complex network of cell signaling pathways. CGAS (cyclic GMP-AMP synthase) is a cytoplasmic DNA sensor that is most known for upregulating interferon-mediated inflammation.
Elizabeth A. Novak +5 more
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Heliyon, 2023 Radioresistance is the major factor of glioblastoma multiforme (GBM) treatment failure and relapse. Hypoxia and autophagy are linked to radioresistance and poor prognosis in solid tumors, but mechanisms remain unknown.
Jielin Wei +8 more
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Expression of beclin-1 in the microenvironment of invasive ductal carcinoma of the breast: correlation with prognosis and the cancer-stromal interaction. [PDF]
PLoS ONE, 2015 We examined the pathobiological properties of beclin-1, which is a key regulator of autophagosome formation in invasive ductal carcinoma of the breast, with a particular focus on the cancer microenvironment.
Akemi Morikawa +6 more
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Targeting Beclin 1 for viral subversion of macroautophagy [PDF]
Autophagy, 2010 We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell.
Gannagé Monique +2 more
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Beclin-1–Dependent Autophagy Improves Outcomes of Pneumonia-Induced Sepsis
Frontiers in Cellular and Infection Microbiology, 2021 ObjectiveWe previously demonstrated that promoting Beclin-1–dependent autophagy is cardiac protective during endotoxemia shock, suggesting that autophagy-based approaches may become a promising therapeutic strategy for sepsis.
Azadeh Nikouee +4 more
doaj +1 more source
An autophagy-independent function of Beclin 1 in cancer [PDF]
Molecular & Cellular Oncology, 2015 The involvement of Beclin 1 in cancer has been attributed primarily to its role in autophagy initiation. Our recent findings identify a novel, alternative mechanism by which Beclin 1 can impact tumor progression, through the regulation of growth factor receptor signaling.
Rohatgi, Rasika, Shaw, Leslie M.
openaire +3 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: Although small cell lung cancer (SCLC) is sensitive to initial chemotherapy, patients experience tumor recurrence and metastasis, leading to treatment failure.
Xiang Yang +4 more
doaj +1 more source
Upregulation of Beclin 1 in the ischemic penumbra [PDF]
Autophagy, 2008 Here we discuss the probable role of autophagy in cerebral ischemia based on our own recent data and the literature. We examined the protein level of Beclin 1 (Bcl-2 interacting protein) and microtubule-associated protein 1 light chain 3 (LC3) which were previously found to promote autophagy.
openaire +2 more sources
Expression of Beclin 1 in Bladder Cancer and Its Clinical Significance
The International Journal of Biological Markers, 2013 Background The aim of this study is to explore the expression of beclin 1, an autophagy gene, in bladder cancer and to evaluate its clinical and prognostic significance in patients with bladder cancer. Methods Beclin 1 expression was examined at mRNA and
Gui-hong Liu +7 more
doaj +1 more source
eLife, 2015 Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are ...
Yongjie Wei +8 more
doaj +1 more source