Results 181 to 190 of about 32,253 (206)

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Nature, 1999
The process of autophagy, or bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important in normal growth control and may be defective in tumour cells. However, little is known about the genetic mediators of autophagy in mammalian cells or their role in tumour development.
X H, Liang, S, Jackson, M, Seaman, K, Brown, B, Kempkes, H, Hibshoosh, B, Levine   +6 more
openaire   +2 more sources

Beclin 1 Complex and Neurodegenerative Disorders

2020
Beclin1 is the mammalian orthologue of yeast Atg6/vacuolar protein sorting-30 (VPS30). Beclin1 interacts with various biological macromolecules like ATG14, BIF-1, NRBF2, RUBICON, UVRAG, AMBRA1, HMGB1, PINK1, and PARKIN. Such interactions promote Beclin1-PI3KC3 complex formation.
Ozaifa Kareem, Ghulam Nabi Bader, Faheem Hyder Pottoo, Mohd. Amir, Md. Abul Barkat, Mukesh Pandey   +5 more
openaire   +1 more source

Beclin-1: Autophagic regulator and therapeutic target in cancer

The International Journal of Biochemistry & Cell Biology, 2013
Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including a short Bcl-2-homology-3 (BH3) motif, a central coiled-
Lei-lei, Fu, Yan, Cheng, Bo, Liu
openaire   +2 more sources

Beclin-1 as an autophagy biomarker in colorectal cancer

Clinica Chimica Acta
Colorectal cancer (CRC) is the leading cause of cancer-related morbidity and mortality attributable to cancer worldwide. Therefore, there is still a need for strong biomarkers that can be used to assist with the diagnosis, prognostication, and therapeutic stratification of patients.
A, Rekha, Riya, Mishra, Chintan, Aundhia, Vaibhav, Rathore, Krishnan, Anand, Poonam, Negi, Sachin Kumar, Singh, Kamal, Dua, Gaurav, Gupta   +8 more
openaire   +2 more sources

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

Proceedings of the National Academy of Sciences of the United States of America, 2021
Lynda Bennett, Beibei Chen, Guanghua Xiao   +2 more
exaly  

The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disorders

Biochimie, 2020
Sargeet Kaur, Harish Changotra
exaly  

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

Cell Research, 2012
Lei Liu, Haiteng Deng, Weijiao Huang
exaly  

Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells

Autophagy, 2009
Hua Zhu, Hao Wu, Jin Ming Yang
exaly  

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Cell Death and Disease, 2010
Peter Vandenabeele, Patrizia Agostinis, T Vanden Berghe   +2 more
exaly  

Beclin 1

2011
openaire   +1 more source