Results 251 to 260 of about 24,253,925 (274)

A study on the mechanism of Beclin-1 m6A modification mediated by catalpol in protection against neuronal injury and autophagy following cerebral ischemia. [PDF]

Mol Med
Liu K, Yao X, Gao J, Wang J, Qi J.
europepmc   +1 more source

MicroRNA-141-3p reduces pulmonary hypoxia/reoxygenation injury through suppression of Beclin-1-dependent autophagy. [PDF]

Aging (Albany NY)
Zhan Y, Li L, Guo C, Zhang Y, Zhao L, Tao Z, Zhang H, Chen S.   +7 more
europepmc   +1 more source

Short-peptide-based enteral nutrition affects rats MDP translocation and protects against gut-lung injury via the PepT1-NOD2-beclin-1 pathway in vivo. [PDF]

Mol Biol Rep
Pang XF, Dai XY, Zhao LJ, Ye YW, Yang XY, Wang HH, Jiang M, Zhu YQ, Shi B.   +8 more
europepmc   +1 more source

Association of Circulating Autophagy Proteins ATG5 and Beclin 1 with Acute Myocardial Infarction in a Case-Control Study.

Cardiology
Grazide MH, Ruidavets JB, Martinet W, Elbaz M, Vindis C.   +4 more
europepmc   +1 more source

VCP/p97 regulates Beclin-1-dependent autophagy initiation [PDF]

Nature Chemical Biology, 2021
Autophagy is an essential cellular process that removes harmful protein species, and autophagy upregulation may be able to protect against neurodegeneration and various pathogens. Here, we have identified the essential protein VCP/p97 as a novel regulator of autophagosome biogenesis, where VCP regulates autophagy induction in two ways, both dependent ...
S. M. Hill, L. Wrobel, A. Ashkenazi, M. Fernandez-Estévez, Keith Tan, R. Bürli, D. Rubinsztein   +6 more
semanticscholar   +3 more sources

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Beclin 1, Bcl-2 and Autophagy.

Advances in Experimental Medicine and Biology, 2019
Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. By investigating the interaction between Bcl-2 and Beclin 1, key molecular mechanisms of mammalian autophagy regulation have been discovered.
Hai-dong Xu, Zheng-Hong Qin
semanticscholar   +3 more sources

Beclin-1 and LC3A expression in cutaneous malignant melanomas

Melanoma Research, 2011
Autophagy is an intracellular pathway for the degradation of long-lived proteins and damaged organelles. It is, in essence, a recycling process allowing cells to survive oxygen and nutrient depletion. The expression of two autophagy-related proteins, beclin 1 and light chain 3A (LC3A) was investigated in 79 nodular cutaneous melanomas. The results were
Efthimios, Sivridis, Michael I, Koukourakis, Savvas E, Mendrinos, Antonios, Karpouzis, Aliki, Fiska, Constantinos, Kouskoukis, Alexandra, Giatromanolaki   +6 more
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Beclin 1 Complex and Neurodegenerative Disorders

2020
Beclin1 is the mammalian orthologue of yeast Atg6/vacuolar protein sorting-30 (VPS30). Beclin1 interacts with various biological macromolecules like ATG14, BIF-1, NRBF2, RUBICON, UVRAG, AMBRA1, HMGB1, PINK1, and PARKIN. Such interactions promote Beclin1-PI3KC3 complex formation.
Ozaifa Kareem, Ghulam Nabi Bader, Faheem Hyder Pottoo, Mohd. Amir, Md. Abul Barkat, Mukesh Pandey   +5 more
openaire   +1 more source

Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I.

Journal of the American Chemical Society, 2020
Autophagy, a catabolic recycling process, has been implicated as a critical pathway in cancer. Its role in maintaining cellular homeostasis helps to nourish hypoxic, nutrient-starved tumors and protects them from chemotherapy-induced death.
I. Pavlinov, M. Salkovski, L. Aldrich
semanticscholar   +1 more source

Regulation of macroautophagy by mTOR and Beclin 1 complexes

Biochimie, 2008
Macroautophagy or autophagy is a vacuolar degradative pathway terminating in the lysosomal compartment after forming a cytoplasmic vacuole or autophagosome that engulfs macromolecules and organelles. The original discovery that ATG (AuTophaGy related) genes in yeast are involved in the formation of autophagosomes has greatly increased our knowledge of ...
Sophie, Pattingre, Lucile, Espert, Martine, Biard-Piechaczyk, Patrice, Codogno   +3 more
openaire   +2 more sources