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Beclin-1: Autophagic regulator and therapeutic target in cancer
The International Journal of Biochemistry & Cell Biology, 2013Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including a short Bcl-2-homology-3 (BH3) motif, a central coiled-
Lei-lei, Fu, Yan, Cheng, Bo, Liu
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Beclin‐1 Is Required for RANKL‐Induced Osteoclast Differentiation
Journal of Cellular Physiology, 2014Beclin‐1 plays a critical role in autophagy; however, it also contributes to other biological processes in a non‐autophagic manner. Although studies have examined the non‐autophagic role of autophagy proteins in the secretory function of osteoclasts (OC), the role of Beclin‐1 is unclear. Here, we examined the role of Beclin‐1 in OC differentiation, and
Yeon-Ho, Chung +9 more
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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Cell, 2005S. Pattingre +8 more
semanticscholar +1 more source
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Nature, 1999X. H. Liang +6 more
semanticscholar +1 more source
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
Nature Structural & Molecular BiologyRui Guo +10 more
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Kinase crosstalk through beclin 1
Nature Reviews Molecular Cell Biology, 2013openaire +1 more source