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Beclin-1 and LC3A expression in cutaneous malignant melanomas

Melanoma Research, 2011
Autophagy is an intracellular pathway for the degradation of long-lived proteins and damaged organelles. It is, in essence, a recycling process allowing cells to survive oxygen and nutrient depletion. The expression of two autophagy-related proteins, beclin 1 and light chain 3A (LC3A) was investigated in 79 nodular cutaneous melanomas. The results were
Efthimios, Sivridis   +6 more
openaire   +2 more sources

Beclin 1, Bcl-2 and Autophagy

2019
Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. By investigating the interaction between Bcl-2 and Beclin 1, key molecular mechanisms of mammalian autophagy regulation have been discovered.
Hai-Dong, Xu, Zheng-Hong, Qin
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Beclin 1 Complex and Neurodegenerative Disorders

2020
Beclin1 is the mammalian orthologue of yeast Atg6/vacuolar protein sorting-30 (VPS30). Beclin1 interacts with various biological macromolecules like ATG14, BIF-1, NRBF2, RUBICON, UVRAG, AMBRA1, HMGB1, PINK1, and PARKIN. Such interactions promote Beclin1-PI3KC3 complex formation.
Ozaifa Kareem   +5 more
openaire   +1 more source

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